ENAH (gene)

Enabled homolog (Drosophila)
PDB rendering of an EVH1 domain.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2HO2​, 2IYB​, 2XQN​, 4MY6​
Identifiers
Symbols	ENAH ; ENA; MENA; NDPP1
External IDs	OMIM: 609061 HomoloGene: 134005 GeneCards: ENAH Gene
Gene ontology Molecular function • actin binding • protein binding • SH3 domain binding • WW domain binding Cellular component • stress fiber • cytoplasm • cytosol • plasma membrane • focal adhesion • lamellipodium • cell junction • filopodium • synapse Biological process • neural tube closure • axon guidance • actin polymerization or depolymerization • intracellular transport • T cell receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55740	13800
Ensembl	ENSG00000154380	ENSMUSG00000022995
UniProt	Q8N8S7	Q03173
RefSeq (mRNA)	NM_001008493	NM_001083120
RefSeq (protein)	NP_001008493	NP_001076589
Location (UCSC)	Chr 1: 225.49 – 225.65 Mb	Chr 1: 181.9 – 182.02 Mb
PubMed search

Protein enabled homolog is a protein that in humans is encoded by the ENAH gene.^[1][2]

Interactions

ENAH (gene) has been shown to interact with ABI1^[3] and ZYX.^[3][4]

References

1. Sazuka T, Tomooka Y, Kathju S, Ikawa Y, Noda M, Kumar S (December 1992). "Identification of a developmentally regulated gene in the mouse central nervous system which encodes a novel proline rich protein". Biochim Biophys Acta 1132 (3): 240–8. doi:10.1016/0167-4781(92)90156-t. PMID 1420303.
2. "Entrez Gene: ENAH enabled homolog (Drosophila)".
3. Tani K, Sato S, Sukezane T, Kojima H, Hirose H, Hanafusa H, Shishido T (2003). "Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase". J. Biol. Chem. 278 (24): 21685–92. doi:10.1074/jbc.M301447200. PMID 12672821.
4. Drees B, Friederich E, Fradelizi J, Louvard D, Beckerle MC, Golsteyn RM (2000). "Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins". J. Biol. Chem. 275 (29): 22503–11. doi:10.1074/jbc.M001698200. PMID 10801818.

Further reading

• Niebuhr K, Ebel F, Frank R; et al. (1997). "A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family.". EMBO J. 16 (17): 5433–44. doi:10.1093/emboj/16.17.5433. PMC 1170174. PMID 9312002.
• Ermekova KS, Zambrano N, Linn H; et al. (1998). "The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled.". J. Biol. Chem. 272 (52): 32869–77. doi:10.1074/jbc.272.52.32869. PMID 9407065.
• Mammoto A, Sasaki T, Asakura T; et al. (1998). "Interactions of drebrin and gephyrin with profilin.". Biochem. Biophys. Res. Commun. 243 (1): 86–9. doi:10.1006/bbrc.1997.8068. PMID 9473484.
• Geese M, Schlüter K, Rothkegel M; et al. (2000). "Accumulation of profilin II at the surface of Listeria is concomitant with the onset of motility and correlates with bacterial speed.". J. Cell. Sci. 113 (8): 1415–26. PMID 10725224.
• Krause M, Sechi AS, Konradt M; et al. (2000). "Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton.". J. Cell Biol. 149 (1): 181–94. doi:10.1083/jcb.149.1.181. PMC 2175102. PMID 10747096.
• Drees B, Friederich E, Fradelizi J; et al. (2000). "Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins.". J. Biol. Chem. 275 (29): 22503–11. doi:10.1074/jbc.M001698200. PMID 10801818.
• Krugmann S, Jordens I, Gevaert K; et al. (2002). "Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex.". Curr. Biol. 11 (21): 1645–55. doi:10.1016/S0960-9822(01)00506-1. PMID 11696321.
• Coutts AS, MacKenzie E, Griffith E, Black DM (2003). "TES is a novel focal adhesion protein with a role in cell spreading.". J. Cell. Sci. 116 (Pt 5): 897–906. doi:10.1242/jcs.00278. PMID 12571287.
• Tani K, Sato S, Sukezane T; et al. (2003). "Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase.". J. Biol. Chem. 278 (24): 21685–92. doi:10.1074/jbc.M301447200. PMID 12672821.
• Garvalov BK, Higgins TE, Sutherland JD; et al. (2003). "The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions.". J. Cell Biol. 161 (1): 33–9. doi:10.1083/jcb.200211015. PMC 2172870. PMID 12695497.
• Park KW, Morrison CM, Sorensen LK; et al. (2003). "Robo4 is a vascular-specific receptor that inhibits endothelial migration.". Dev. Biol. 261 (1): 251–67. doi:10.1016/S0012-1606(03)00258-6. PMID 12941633.
• Giesemann T, Schwarz G, Nawrotzki R; et al. (2003). "Complex formation between the postsynaptic scaffolding protein gephyrin, profilin, and Mena: a possible link to the microfilament system.". J. Neurosci. 23 (23): 8330–9. PMID 12967995.
• Salazar MA, Kwiatkowski AV, Pellegrini L; et al. (2004). "Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton.". J. Biol. Chem. 278 (49): 49031–43. doi:10.1074/jbc.M308104200. PMID 14506234.
• Stüven T, Hartmann E, Görlich D (2003). "Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes.". EMBO J. 22 (21): 5928–40. doi:10.1093/emboj/cdg565. PMC 275422. PMID 14592989.
• Di Modugno F, Bronzi G, Scanlan MJ; et al. (2004). "Human Mena protein, a serex-defined antigen overexpressed in breast cancer eliciting both humoral and CD8+ T-cell immune response.". Int. J. Cancer 109 (6): 909–18. doi:10.1002/ijc.20094. PMID 15027125.
• Tanoue T, Takeichi M (2004). "Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact.". J. Cell Biol. 165 (4): 517–28. doi:10.1083/jcb.200403006. PMC 2172355. PMID 15148305.
• Krause M, Leslie JD, Stewart M; et al. (2004). "Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics.". Dev. Cell 7 (4): 571–83. doi:10.1016/j.devcel.2004.07.024. PMID 15469845.