EPB49

Dematin actin binding protein
PDB rendering based on 1qzp.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1QZP​, 1ZV6​
Identifiers
Symbols	DMTN ; DMT; EPB49
External IDs	OMIM: 125305 MGI: 99670 HomoloGene: 1496 GeneCards: DMTN Gene
Gene ontology Molecular function • actin binding • receptor binding • protein binding • spectrin binding • protein self-association Cellular component • cytosol • actin filament • plasma membrane • endomembrane system • spectrin-associated cytoskeleton • actin cytoskeleton • cytoplasmic membrane-bounded vesicle • cortical cytoskeleton • platelet dense tubular network membrane • cell projection membrane • perinuclear region of cytoplasm • neuronal postsynaptic density Biological process • protein complex assembly • cytoskeleton organization • regulation of cell shape • regulation of lamellipodium assembly • positive regulation of fibroblast migration • negative regulation of peptidyl-threonine phosphorylation • negative regulation of cell-substrate adhesion • actin cytoskeleton organization • positive regulation of blood coagulation • regulation of actin cytoskeleton organization • negative regulation of peptidyl-serine phosphorylation • calcium-mediated signaling using intracellular calcium source • calcium-mediated signaling using extracellular calcium source • erythrocyte development • negative regulation of peptidyl-tyrosine phosphorylation • actin filament bundle assembly • regulation of filopodium assembly • actin filament capping • negative regulation of focal adhesion assembly • transmembrane transport • protein secretion by platelet • cellular response to calcium ion • cellular response to cAMP • positive regulation of wound healing • negative regulation of protein targeting to membrane • actin filament reorganization • negative regulation of substrate adhesion-dependent cell spreading • positive regulation of substrate adhesion-dependent cell spreading • positive regulation of platelet aggregation • positive regulation of integrin-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2039	13829
Ensembl	ENSG00000158856	ENSMUSG00000022099
UniProt	Q08495	Q9WV69
RefSeq (mRNA)	NM_001114135	NM_001252662
RefSeq (protein)	NP_001107607	NP_001239591
Location (UCSC)	Chr 8: 22.05 – 22.08 Mb	Chr 14: 70.6 – 70.64 Mb
PubMed search

Dematin is a protein that in humans is encoded by the EPB49 gene.^[1][2][3]

References

1. Rana AP, Ruff P, Maalouf GJ, Speicher DW, Chishti AH (Aug 1993). "Cloning of human erythroid dematin reveals another member of the villin family". Proc Natl Acad Sci U S A 90 (14): 6651–5. doi:10.1073/pnas.90.14.6651. PMC 46990. PMID 8341682.
2. Khanna R, Chang SH, Andrabi S, Azam M, Kim A, Rivera A, Brugnara C, Low PS, Liu SC, Chishti AH (May 2002). "Headpiece domain of dematin is required for the stability of the erythrocyte membrane". Proc Natl Acad Sci U S A 99 (10): 6637–42. doi:10.1073/pnas.052155999. PMC 124455. PMID 12011427.
3. "Entrez Gene: EPB49 erythrocyte membrane protein band 4.9 (dematin)".

Further reading

• Azim AC, Knoll JH, Beggs AH, Chishti AH (1995). "Isoform cloning, actin binding, and chromosomal localization of human erythroid dematin, a member of the villin superfamily". J. Biol. Chem. 270 (29): 17407–13. doi:10.1074/jbc.270.29.17407. PMID 7615546.
• Azim AC, Marfatia SM, Korsgren C; et al. (1996). "Human erythrocyte dematin and protein 4.2 (pallidin) are ATP binding proteins". Biochemistry 35 (9): 3001–6. doi:10.1021/bi951745y. PMID 8608138.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Millar JK, Christie S, Porteous DJ (2004). "Yeast two-hybrid screens implicate DISC1 in brain development and function". Biochem. Biophys. Res. Commun. 311 (4): 1019–25. doi:10.1016/j.bbrc.2003.10.101. PMID 14623284.
• Frank BS, Vardar D, Chishti AH, McKnight CJ (2004). "The NMR structure of dematin headpiece reveals a dynamic loop that is conformationally altered upon phosphorylation at a distal site". J. Biol. Chem. 279 (9): 7909–16. doi:10.1074/jbc.M310524200. PMID 14660664.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Vermeulen W, Van Troys M, Bourry D; et al. (2006). "Identification of the PXW sequence as a structural gatekeeper of the headpiece C-terminal subdomain fold". J. Mol. Biol. 359 (5): 1277–92. doi:10.1016/j.jmb.2006.04.042. PMID 16697408.