EPN2
| Epsin 2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | EPN2 ; EHB21 | ||||||||||||
| External IDs | OMIM: 607263 MGI: 1333766 HomoloGene: 40710 GeneCards: EPN2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 22905 | 13855 | |||||||||||
| Ensembl | ENSG00000072134 | ENSMUSG00000001036 | |||||||||||
| UniProt | O95208 | Q8CHU3 | |||||||||||
| RefSeq (mRNA) | NM_001102664 | NM_001252188 | |||||||||||
| RefSeq (protein) | NP_001096134 | NP_001239117 | |||||||||||
| Location (UCSC) |
Chr 17: 19.22 – 19.34 Mb |
Chr 11: 61.52 – 61.58 Mb | |||||||||||
| PubMed search | |||||||||||||
Epsin-2 is a protein that in humans is encoded by the EPN2 gene.[1][2]
This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The protein is thought to be involved in clathrin-mediated endocytosis. Alternate splicing of this gene results in two transcript variants encoding different isoforms.[2]
References
- ↑ Rosenthal JA, Chen H, Slepnev VI, Pellegrini L, Salcini AE, Di Fiore PP, De Camilli P (Dec 1999). "The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module". J Biol Chem 274 (48): 33959–65. doi:10.1074/jbc.274.48.33959. PMID 10567358.
- 1 2 "Entrez Gene: EPN2 epsin 2".
Further reading
- Salcini AE, Confalonieri S, Doria M; et al. (1997). "Binding specificity and in vivo targets of the EH domain, a novel protein–protein interaction module". Genes Dev. 11 (17): 2239–49. doi:10.1101/gad.11.17.2239. PMC 275390. PMID 9303539.
- Yamabhai M, Hoffman NG, Hardison NL; et al. (1998). "Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains". J. Biol. Chem. 273 (47): 31401–7. doi:10.1074/jbc.273.47.31401. PMID 9813051.
- Kikuno R, Nagase T, Ishikawa K; et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
- Ford MG, Mills IG, Peter BJ; et al. (2002). "Curvature of clathrin-coated pits driven by epsin". Nature 419 (6905): 361–6. doi:10.1038/nature01020. PMID 12353027.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Hussain NK, Yamabhai M, Bhakar AL; et al. (2003). "A role for epsin N-terminal homology/AP180 N-terminal homology (ENTH/ANTH) domains in tubulin binding". J. Biol. Chem. 278 (31): 28823–30. doi:10.1074/jbc.M300995200. PMID 12750376.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Colland F, Jacq X, Trouplin V; et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Jin J, Smith FD, Stark C; et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
- Ballif BA, Villén J, Beausoleil SA; et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
- Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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