ERC1

ELKS/RAB6-interacting/CAST family member 1
Identifiers
Symbols	ERC1 ; Cast2; ELKS; ERC-1; RAB6IP2
External IDs	OMIM: 607127 MGI: 2151013 HomoloGene: 14229 GeneCards: ERC1 Gene
Gene ontology Molecular function • protein binding • Rab GTPase binding • PDZ domain binding • leucine zipper domain binding Cellular component • Golgi membrane • cytoplasm • IkappaB kinase complex • presynaptic membrane • synapse • presynaptic active zone Biological process • regulation of transcription, DNA-templated • I-kappaB phosphorylation • multicellular organismal development • protein transport • retrograde transport, endosome to Golgi • positive regulation of NF-kappaB transcription factor activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23085	111173
Ensembl	ENSG00000082805	ENSMUSG00000030172
UniProt	Q8IUD2	Q99MI1
RefSeq (mRNA)	NM_001301248	NM_053204
RefSeq (protein)	NP_001288177	NP_444434
Location (UCSC)	Chr 12: 0.99 – 1.5 Mb	Chr 6: 119.57 – 119.85 Mb
PubMed search

ELKS/RAB6-interacting/CAST family member 1 is a protein that in humans is encoded by the ERC1 gene.^[1][2][3]

The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13). Multiple transcript variants encoding different isoforms have been found for this gene.^[3]

Interactions

ERC1 has been shown to interact with RAB6A.^[2]

References

1. Yokota T, Nakata T, Minami S, Inazawa J, Emi M (Apr 2000). "Genomic organization and chromosomal mapping of ELKS, a gene rearranged in a papillary thyroid carcinoma". J Hum Genet 45 (1): 6–11. doi:10.1007/s100380050002. PMID 10697956.
2. Monier S, Jollivet F, Janoueix-Lerosey I, Johannes L, Goud B (Apr 2002). "Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport". Traffic 3 (4): 289–97. doi:10.1034/j.1600-0854.2002.030406.x. PMID 11929610.
3. "Entrez Gene: ERC1 ELKS/RAB6-interacting/CAST family member 1".

Further reading

• Nakajima D, Okazaki N, Yamakawa H; et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Armour JA, Crosier M, Jeffreys AJ (1992). "Human minisatellite alleles detectable only after PCR amplification.". Genomics 12 (1): 116–24. doi:10.1016/0888-7543(92)90413-M. PMID 1733848.
• Nakata T, Kitamura Y, Shimizu K; et al. (1999). "Fusion of a novel gene, ELKS, to RET due to translocation t(10;12)(q11;p13) in a papillary thyroid carcinoma.". Genes Chromosomes Cancer 25 (2): 97–103. doi:10.1002/(SICI)1098-2264(199906)25:2<97::AID-GCC4>3.0.CO;2-L. PMID 10337992.
• Kikuno R, Nagase T, Ishikawa K; et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
• Nakata T, Yokota T, Emi M, Minami S (2002). "Differential expression of multiple isoforms of the ELKS mRNAs involved in a papillary thyroid carcinoma.". Genes Chromosomes Cancer 35 (1): 30–7. doi:10.1002/gcc.10095. PMID 12203787.
• Wang Y, Liu X, Biederer T, Südhof TC (2002). "A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones.". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14464–9. doi:10.1073/pnas.182532999. PMC 137906. PMID 12391317.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ko J, Na M, Kim S; et al. (2004). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins.". J. Biol. Chem. 278 (43): 42377–85. doi:10.1074/jbc.M307561200. PMID 12923177.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Deguchi-Tawarada M, Inoue E, Takao-Rikitsu E; et al. (2004). "CAST2: identification and characterization of a protein structurally related to the presynaptic cytomatrix protein CAST.". Genes Cells 9 (1): 15–23. doi:10.1111/j.1356-9597.2004.00697.x. PMID 14723704.
• Ducut Sigala JL, Bottero V, Young DB; et al. (2004). "Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit.". Science 304 (5679): 1963–7. doi:10.1126/science.1098387. PMID 15218148.
• Jin J, Smith FD, Stark C; et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Beausoleil SA, Villén J, Gerber SA; et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.