ERH (gene)
| Enhancer of rudimentary homolog (Drosophila) | |||||||||||||
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PDB rendering based on 1w9g. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | ERH ; DROER | ||||||||||||
| External IDs | OMIM: 601191 MGI: 108089 HomoloGene: 3274 GeneCards: ERH Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 2079 | 13877 | |||||||||||
| Ensembl | ENSG00000100632 | ENSMUSG00000021131 | |||||||||||
| UniProt | P84090 | P84089 | |||||||||||
| RefSeq (mRNA) | NM_004450 | NM_007951 | |||||||||||
| RefSeq (protein) | NP_004441 | NP_031977 | |||||||||||
| Location (UCSC) |
Chr 14: 69.38 – 69.4 Mb |
Chr 12: 80.63 – 80.64 Mb | |||||||||||
| PubMed search | |||||||||||||
| Enhancer of rudimentary | |||||||||
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 crystal structure of enhancer of rudimentary homologue (erh) | |||||||||
| Identifiers | |||||||||
| Symbol | ER | ||||||||
| Pfam | PF01133 | ||||||||
| InterPro | IPR000781 | ||||||||
| PROSITE | PDOC00732 | ||||||||
| SCOP | 1j24 | ||||||||
| SUPERFAMILY | 1j24 | ||||||||
| TCDB | 3.A.16 | ||||||||
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In molecular biology, Enhancer of rudimentary homolog is a protein that in humans is encoded by the ERH gene.[1][2][3]
The Drosophila protein enhancer of rudimentary protein is a small protein of 104 amino acids. It has been found to be an enhancer of the rudimentary gene, involved in pyrimidine biosynthesis.[4]
From an evolutionary point of view, enhancer of rudimentary is highly conserved and has been found to exist in probably all multicellular eukaryotic organisms.[2] It has been proposed that this protein plays a role in the cell cycle.
References
- ↑ Isomura M, Okui K, Fujiwara T, Shin S, Nakamura Y (Sep 1996). "Cloning and mapping of a novel human cDNA homologous to DROER, the enhancer of the Drosophila melanogaster rudimentary gene". Genomics 32 (1): 125–7. doi:10.1006/geno.1996.0086. PMID 8786099.
- 1 2 Gelsthorpe M, Pulumati M, McCallum C, Dang-Vu K, Tsubota SI (Apr 1997). "The putative cell cycle gene, enhancer of rudimentary, encodes a highly conserved protein found in plants and animals". Gene 186 (2): 189–95. doi:10.1016/S0378-1119(96)00701-9. PMID 9074495.
- ↑ "Entrez Gene: ERH enhancer of rudimentary homolog (Drosophila)".
- ↑ Wojcik, E.; Murphy, A. M.; Fares, H.; Dang-Vu, K.; Tsubota, S. I. (1994). "Enhancer of rudimentaryp1, e(r)p1, a highly conserved enhancer of the rudimentary gene". Genetics 138 (4): 1163–1170. PMC 1206255. PMID 7896098.
Further reading
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Andersen JS, Lam YW, Leung AK; et al. (2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
- Amente S, Napolitano G, Licciardo P; et al. (2005). "Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation". FEBS Lett. 579 (3): 683–9. doi:10.1016/j.febslet.2004.12.045. PMID 15670829.
- Wan C, Tempel W, Liu ZJ; et al. (2005). "Structure of the conserved transcriptional repressor enhancer of rudimentary homolog". Biochemistry 44 (13): 5017–23. doi:10.1021/bi047785w. PMID 15794639.
- Stelzl U, Worm U, Lalowski M; et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
- Jin T, Guo F, Serebriiskii IG; et al. (2007). "A 1.55 A resolution X-ray crystal structure of HEF2/ERH and insights into its transcriptional and cell-cycle interaction networks". Proteins 68 (2): 427–37. doi:10.1002/prot.21343. PMID 17444515.
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This article incorporates text from the public domain Pfam and InterPro IPR000781
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