Echinocandin B

Echinocandin B
Identifiers
54651-05-7 YesY
ChemSpider 28296438 N
Jmol interactive 3D Image
MeSH echinocandin+B
PubChem 6436199
Properties
C52H81N7O16
Molar mass 1060.24 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Echinocandin B, a lipopeptide, is a naturally occurring cyclic hexapeptide with a linoleoyl side chain. It belongs to a class of antifungal agents called echinocandins, which inhibits the synthesis of glucan, a major component of the fungal cell wall, via noncompetitive inhibition of a crucial enzyme, β-(1,3)-D-glucan synthase. Echinocandin B is a fermentation product of Aspergillus nidulans and the closely related species, A. rugulosus;[1] discovered in 1974 in A. nidulans var. echinulatus strain A 32204 in Germany,[2] it was the first of the echinocandin class of antifungals.

Echninocandin B can undergo deacylation (removal of the lipid side chain) by the action of a deacylase enzyme from the filamentous bacterium Actinoplanes utahensis, which catalyzes the cleavage of the linoleoyl side chain;[3] in three subsequent synthetic steps, including a chemical reacylation, the antifungal drug anidulafungin[4] is synthesized.

References

  1. Denning DW (1997). "Echinocandins and pneumocandins - a new antifungal class with a novel mode of action". J Antimicrob Chemother 40 (5): 611–614. doi:10.1093/jac/dkf045. PMID 9421307.
  2. Nyfeler R, Keller-Schierlein W (1974). "Metabolites of microorganisms. 143. Echinocandin B, a novel polypeptide-antibiotic from Aspergillus nidulans var. echinulatus: isolation and structural components". Helv Chim Acta 57 (8): 2459–2477. doi:10.1002/hlca.19740570818. PMID 4613708.
  3. Lei Shao, Jian Li, Aijuan Liu, Qing Chang, Huimin Lin, Daijie Chen (2013). "Efficient Bioconversion of Echinocandin B to Its Nucleus by Overexpression of Deacylase Genes in Different Host Strains". Applied and Environmental Microbiology 79 (4): 1126–1133. doi:10.1128/AEM.02792-12. PMC 3568618. PMID 23220968.
  4. "Anidulafungin EMA Europa" (PDF).


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