Edward Wild (neuroscientist)

Dr Edward John Wild

Edward Wild in March 2015

Edward Wild in March 2015
Born (1978-12-17) 17 December 1978[1]
Residence London, UK
Nationality British
Fields Neuroscience
Institutions UCL Institute of Neurology;
National Hospital for Neurology and Neurosurgery
Alma mater Christ's College, Cambridge (1996-2001)
University College London (2005-2008)
Thesis Identification and evaluation of biomarkers for Huntington's disease (2009)
Doctoral advisor Sarah Tabrizi
Known for Huntington's disease research and outreach
Notable awards Huntington’s Disease Society of America Researcher of the Year, 2014;
Huntington Society of Canada Community Leadership Award, 2013;
Huntington Study Group Insight of the Year, 2015.
Website
edwild.com
hdbuzz.net
twitter.com/dredwild

Edward Wild, also known as Ed Wild, is a British neurologist and neuroscientist in the field of Huntington’s disease and advocate for scientific outreach to the public. He co-founded the Huntington’s research news platform HDBuzz. Wild is a Clinician Scientist at UCL Institute of Neurology.

Career

Wild studied medicine at Christ's College, University of Cambridge.[2][3] In his early career he studied and published on the neurological phenomenon of déjà vu.[4][5] He undertook a PhD at UCL Institute of Neurology, Queen Square, London,[6] publishing numerous peer-reviewed works establishing biomarkers for Huntington's disease using magnetic resonance imaging measures of brain atrophy[7][8][9][10][11][12] and biochemical analysis of blood.[13][14][15][16][17][18][19] His work has established him as an expert in the field of clinical research and biomarkers for Huntington's disease.[20][21][22][23][24][25][26] He described a novel pathogenic pathway of immune activation in Huntington’s[27][28][29][30] which led to clinical trials of immune-targeted therapies.[31] Wild's PhD work was awarded the 2009 Queen Square Prize in Neurology.[2][32] In 2015 he published the first successful detection and quantification of mutant huntingtin protein (the known cause of Huntington’s) in human cerebrospinal fluid, using a novel ‘single-molecule counting’ immunoassay.[33] This development won Wild the Huntington Study Group ‘Insight of the Year’ award as one of the major research findings of 2015.[34]

Wild is also an authority on Huntington's disease phenocopy or 'lookalike' syndromes.[21][35][36][37][38] He serves on the Medical Advisory Panel of the UK Huntington's Disease Association,[39] the Editorial Board of the Journal of Huntington's Disease[40] and the Review Board of PLoS Currents: Huntington's Disease,[41] and is a founder member of the advisory panel to the UK All-Party Parliamentary Group on Huntington's Disease.[42][43][44]

In 2015 Wild was awarded an MRC Clinician Scientist Fellowship and appointed Honorary Consultant at the National Hospital for Neurology & Neurosurgery.[2][24] He has authored over 40 peer-reviewed publications[45][46] and 5 peer-reviewed chapters in academic books on neurodegeneration.[12][20][21][22][38]

Public Engagement Work

Wild is an advocate for public engagement and outreach by scientists. Alongside US neuroscientist Dr Jeff Carroll and Emmy award-winning journalist and HD patient advocate Charles Sabine, Wild delivers plain-language digests of research news for patients and family members at major international scientific conferences including the World Congress on Huntington's Disease,[47] the European Huntington's Disease Network Congress[48] and the Conventions of the main US,[49] Canadian[50] and UK Huntington’s Disease patient associations. In 2013 he addressed the 2013 GET Conference alongside Steven Pinker.[32]

In 2010 Wild and Carroll founded HDBuzz, an online source of accessible news about Huntington's disease research, written by scientists.[51][52] HDBuzz was awarded the 2012 Community Development Award from the Huntington Society of Canada,[53] and the 2014 Huntington’s Disease Society of America Research Award.[54] HDBuzz was the subject of an article in the scientific journal Trends in Molecular Medicine in October 2011 entitled 'HDBuzz: empowering patients through accessible education'.[52]

Wild appeared in the documentary feature film The Inheritance[55][56] and judged the 2015 British Library / Europe PubMed Central 'Access to Understanding' contest for science writers.[57] He has also appeared on the BBC Radio Naked Scientists programme.[58]

References

  1. ↑ "Edward Wild - resources". edwild.com. Retrieved 15 April 2016.
  2. 1 2 3 "Dr Edward Wild Consultant Profile". University College London Hospitals NHS Foundation Trust. Retrieved 30 March 2016.
  3. ↑ "Christ's College Cambridge Medical Alumni Association".
  4. ↑ Wild, Edward (2005-01-01). "Deja vu in neurology". Journal of Neurology 252 (1): 1–7. doi:10.1007/s00415-005-0677-3. ISSN 0340-5354. PMID 15654548.
  5. ↑ Phillips, Helen (25 March 2009). "Déjà vu: Where fact meets fantasy" (PDF). New Scientist. New Scientist. pp. 3, 5. Archived from the original on 26 March 2009. Retrieved 31 March 2016.
  6. ↑ Wild, Edward. "Identification and evaluation of biomarkers for Huntington's disease (PhD Thesis)". UCL Discovery Institutional Document Repository. University College London.
  7. ↑ Wild, Edward J.; Henley, Susie M. D.; Hobbs, Nicola Z.; Frost, Chris; MacManus, David G.; Barker, Roger A.; Fox, Nick C.; Tabrizi, Sarah J. (2010-05-15). "Rate and acceleration of whole-brain atrophy in premanifest and early Huntington's disease". Movement Disorders: Official Journal of the Movement Disorder Society 25 (7): 888–895. doi:10.1002/mds.22969. ISSN 1531-8257. PMID 20461806.
  8. ↑ Henley, Susie M. D.; Wild, Edward J.; Hobbs, Nicola Z.; Frost, Chris; MacManus, David G.; Barker, Roger A.; Fox, Nick C.; Tabrizi, Sarah J. (2009-04-30). "Whole-brain atrophy as a measure of progression in premanifest and early Huntington's disease". Movement Disorders: Official Journal of the Movement Disorder Society 24 (6): 932–936. doi:10.1002/mds.22485. ISSN 1531-8257. PMID 19243073.
  9. ↑ Henley, Susie M. D.; Wild, Edward J.; Hobbs, Nicola Z.; Scahill, Rachael I.; Ridgway, Gerard R.; Macmanus, David G.; Barker, Roger A.; Fox, Nick C.; Tabrizi, Sarah J. (2009-02-01). "Relationship between CAG repeat length and brain volume in premanifest and early Huntington's disease". Journal of Neurology 256 (2): 203–212. doi:10.1007/s00415-009-0052-x. ISSN 1432-1459. PMID 19266143.
  10. ↑ Hobbs, Nicola Z.; Henley, Susie M. D.; Wild, Edward J.; Leung, Kelvin K.; Frost, Chris; Barker, Roger A.; Scahill, Rachael I.; Barnes, Josephine; Tabrizi, Sarah J. (2009-10-01). "Automated quantification of caudate atrophy by local registration of serial MRI: evaluation and application in Huntington's disease". NeuroImage 47 (4): 1659–1665. doi:10.1016/j.neuroimage.2009.06.003. ISSN 1095-9572. PMID 19523522.
  11. ↑ Hobbs, Nicola Z.; Henley, Susie M. D.; Ridgway, Gerard R.; Wild, Edward J.; Barker, Roger A.; Scahill, Rachael I.; Barnes, Josephine; Fox, Nick C.; Tabrizi, Sarah J. (2010-07-01). "The progression of regional atrophy in premanifest and early Huntington's disease: a longitudinal voxel-based morphometry study". Journal of Neurology, Neurosurgery, and Psychiatry 81 (7): 756–763. doi:10.1136/jnnp.2009.190702. ISSN 1468-330X. PMID 19955112.
  12. 1 2 Wild, Edward; Hobbs, Nicola; Henley, Susie (2011). "Huntington's Disease and Dementia". Neuroimaging in Dementia. Springer-Verlag. ISBN 3642008178.
  13. ↑ Wild, Edward J.; Petzold, Axel; Keir, Geoff; Tabrizi, Sarah J. (2007-05-07). "Plasma neurofilament heavy chain levels in Huntington's disease". Neuroscience Letters 417 (3): 231–233. doi:10.1016/j.neulet.2007.02.053. ISSN 0304-3940. PMID 17363167.
  14. ↑ Runne, Heike; Kuhn, Alexandre; Wild, Edward J.; Pratyaksha, Wirahpati; Kristiansen, Mark; Isaacs, Jeremy D.; Régulier, Etienne; Delorenzi, Mauro; Tabrizi, Sarah J. (2007-09-04). "Analysis of potential transcriptomic biomarkers for Huntington's disease in peripheral blood". Proceedings of the National Academy of Sciences of the United States of America 104 (36): 14424–14429. doi:10.1073/pnas.0703652104. ISSN 0027-8424. PMC 1964868. PMID 17724341.
  15. ↑ Wild, Edward J.; Tabrizi, Sarah J. (2008-01-01). "Biomarkers for Huntington's disease". Expert Opinion on Medical Diagnostics 2 (1): 47–62. doi:10.1517/17530059.2.1.47. ISSN 1753-0059. PMID 23485116.
  16. ↑ Leoni, Valerio; Mariotti, Caterina; Tabrizi, Sarah J.; Valenza, Marta; Wild, Edward J.; Henley, Susie M. D.; Hobbs, Nicola Z.; Mandelli, Maria Luisa; Grisoli, Marina (2008-11-01). "Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease". Brain: A Journal of Neurology 131 (Pt 11): 2851–2859. doi:10.1093/brain/awn212. ISSN 1460-2156. PMID 18772220.
  17. ↑ Munsie, Lise; Caron, Nicholas; Atwal, Randy Singh; Marsden, Ian; Wild, Edward J.; Bamburg, James R.; Tabrizi, Sarah J.; Truant, Ray (2011-05-15). "Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease". Human Molecular Genetics 20 (10): 1937–1951. doi:10.1093/hmg/ddr075. ISSN 1460-2083. PMC 3080606. PMID 21355047.
  18. ↑ Zuccato, Chiara; Marullo, Manuela; Vitali, Barbara; Tarditi, Alessia; Mariotti, Caterina; Valenza, Marta; Lahiri, Nayana; Wild, Edward J.; Sassone, Jenny (2011-01-01). "Brain-derived neurotrophic factor in patients with Huntington's disease". PloS One 6 (8): e22966. doi:10.1371/journal.pone.0022966. ISSN 1932-6203. PMC 3155522. PMID 21857974.
  19. ↑ Weiss, Andreas; Träger, Ulrike; Wild, Edward J.; Grueninger, Stephan; Farmer, Ruth; Landles, Christian; Scahill, Rachael I.; Lahiri, Nayana; Haider, Salman (2012-10-01). "Mutant huntingtin fragmentation in immune cells tracks Huntington's disease progression". The Journal of Clinical Investigation 122 (10): 3731–3736. doi:10.1172/JCI64565. ISSN 1558-8238. PMC 3461928. PMID 22996692.
  20. 1 2 Wild, Edward; Tabrizi, Sarah (2014). "Premanifest and Early Huntington's Disease". Huntington's Disease (4th ed.). Oxford University Press. ISBN 0199929149.
  21. 1 2 3 Haider, Salman; Wild, Edward; Tabrizi, Sarah (2016). "Huntington's Disease and Other Choreas". Neurodegeneration. Oxford University Press. ISBN 0470672684.
  22. 1 2 Tabrizi, Sarah; Wild, Edward (2012). "Huntington's Disease". Neurogenetics: a Guide for Clinicians. Cambridge University Press. ISBN 052154372X.
  23. ↑ "Genetic Brain Disease 'Far More Common'". Sky News. Retrieved 2016-03-31.
  24. 1 2 Check Hayden, Erika (23 February 2016). "Should you edit your children’s genes?". Nature 530 (7591): 402–405. doi:10.1038/530402a.
  25. ↑ Bates, Gillian P.; Dorsey, Ray; Gusella, James F.; Hayden, Michael R.; Kay, Chris; Leavitt, Blair R.; Nance, Martha; Ross, Christopher A.; Scahill, Rachael I. (2015-04-23). "Huntington disease". Nature Reviews Disease Primers. doi:10.1038/nrdp.2015.5.
  26. ↑ Ross, Christopher A.; Aylward, Elizabeth H.; Wild, Edward J.; Langbehn, Douglas R.; Long, Jeffrey D.; Warner, John H.; Scahill, Rachael I.; Leavitt, Blair R.; Stout, Julie C. (2014-04-01). "Huntington disease: natural history, biomarkers and prospects for therapeutics". Nature Reviews. Neurology 10 (4): 204–216. doi:10.1038/nrneurol.2014.24. ISSN 1759-4766. PMID 24614516.
  27. ↑ Björkqvist, M; Wild, EJ; Thiele, J; Silvestroni, A; Andre, R; Lahiri, N; Raibon, E; Lee, RV; Benn, CL; Soulet, D; Magnusson, A; Woodman, B; Landles, C; Pouladi, MA; Hayden, MR; Khalili-Shirazi, A; Lowdell, MW; Brundin, P; Bates, GP; Leavitt, BR; Möller, T; Tabrizi, SJ (4 August 2008). "A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease.". The Journal of experimental medicine 205 (8): 1869–77. PMID 18625748.
  28. ↑ Dalrymple, A; Wild, EJ; Joubert, R; Sathasivam, K; Björkqvist, M; Petersén, A; Jackson, GS; Isaacs, JD; Kristiansen, M; Bates, GP; Leavitt, BR; Keir, G; Ward, M; Tabrizi, SJ (July 2007). "Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates.". Journal of proteome research 6 (7): 2833–40. PMID 17552550.
  29. ↑ Wild, Edward; Björkqvist, Maria; Tabrizi, Sarah J. (2008-12-01). "Immune markers for Huntington's disease?". Expert Review of Neurotherapeutics 8 (12): 1779–1781. doi:10.1586/14737175.8.12.1779. ISSN 1744-8360. PMID 19086873.
  30. ↑ Björkqvist, Maria; Wild, Edward J.; Tabrizi, Sarah J. (2009-10-15). "Harnessing immune alterations in neurodegenerative diseases". Neuron 64 (1): 21–24. doi:10.1016/j.neuron.2009.09.034. ISSN 1097-4199. PMID 19840543.
  31. ↑ "A Clinical Study in Subjects With Huntington's Disease to Assess the Efficacy and Safety of Three Oral Doses of Laquinimod - Full Text View - ClinicalTrials.gov". clinicaltrials.gov. Retrieved 2016-03-31.
  32. 1 2 "GET :: Genomes Environments Traits". www.getconference.org. Retrieved 2016-03-31.
  33. ↑ Wild, EJ; Boggio, R; Langbehn, D; Robertson, N; Haider, S; Miller, JR; Zetterberg, H; Leavitt, BR; Kuhn, R; Tabrizi, SJ; Macdonald, D; Weiss, A (May 2015). "Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients.". The Journal of clinical investigation 125 (5): 1979–86. PMID 25844897.
  34. ↑ "Announcing HSG’s 2015 Award Winners". Huntington Study Group. Retrieved 2016-03-31.
  35. ↑ Hensman Moss, Davina J.; Poulter, Mark; Beck, Jon; Hehir, Jason; Polke, James M.; Campbell, Tracy; Adamson, Garry; Mudanohwo, Ese; McColgan, Peter (2014-01-28). "C9orf72 expansions are the most common genetic cause of Huntington disease phenocopies". Neurology 82 (4): 292–299. doi:10.1212/WNL.0000000000000061. ISSN 1526-632X. PMC 3929197. PMID 24363131.
  36. ↑ Wild, Edward J.; Mudanohwo, Ese E.; Sweeney, Mary G.; Schneider, Susanne A.; Beck, Jon; Bhatia, Kailash P.; Rossor, Martin N.; Davis, Mary B.; Tabrizi, Sarah J. (2008-04-15). "Huntington's disease phenocopies are clinically and genetically heterogeneous". Movement Disorders: Official Journal of the Movement Disorder Society 23 (5): 716–720. doi:10.1002/mds.21915. ISSN 1531-8257. PMID 18181206.
  37. ↑ Wild, Edward J.; Tabrizi, Sarah J. (2007-12-01). "Huntington's disease phenocopy syndromes". Current Opinion in Neurology 20 (6): 681–687. doi:10.1097/WCO.0b013e3282f12074. ISSN 1350-7540. PMID 17992089.
  38. 1 2 Wild, Edward J; Tabrizi, Sarah (2013). "Huntington's Disease Look-alike Syndromes". Oxford Textbooks in Clinical Neurology: Movement Disorders. Oxford University Press. ISBN 0199609535.
  39. ↑ "HDA - Research - Medical advisory panel". hda.org.uk. Retrieved 2016-03-31.
  40. ↑ "IOS Press". www.iospress.nl. Retrieved 2016-03-31.
  41. ↑ "Review Board – PLOS Currents Huntington Disease". currents.plos.org. Retrieved 2016-03-31.
  42. ↑ "HDA - HDA News - APPG meeting on 21 October, 2014". hda.org.uk. Retrieved 2016-03-31.
  43. ↑ Harrison, Jacqueline. "The ‘hidden no more’ mass lobby June 2010 - using oral histories and cultural representations to explore the concealment of Huntington’s disease. (Masters Thesis)". University of Huddersfield Repository.
  44. ↑ "Massive Underestimation In The Prevalence Of Huntington's Disease In The UK Population". Science 2.0. Retrieved 2016-03-31.
  45. ↑ "Dr Edward J Wild - Google Scholar Citations". scholar.google.co.uk. Retrieved 2016-03-31.
  46. ↑ "Dr Edward Wild Iris Profile". Institutional Research Information Service. Retrieved 30 March 2016.
  47. ↑ "HD Buzz". YouTube.
  48. ↑ "Nightly News from EHDN in Prague 2010". Vimeo. Retrieved 2016-03-31.
  49. ↑ HD Buzz (2013-10-26), The Drugs Are Coming: Dr Jeff Carroll and Dr Ed Wild at HDSA Convention 2013, retrieved 2016-03-31
  50. ↑ "Reflections on Winnipeg". Huntington Society of Canada. Retrieved 2016-03-31.
  51. ↑ "Huntington’s disease research news. In plain language.". HDBuzz.
  52. 1 2 Wild, Edward J; Carroll, Jeffrey B (January 2012). "HDBuzz: empowering patients through accessible education". Trends in Molecular Medicine 18 (1): 1–3. doi:10.1016/j.molmed.2011.09.003.
  53. ↑ "World-Renowned International Huntington Neurologists and Researchers to be featured at the Huntington Society of Canada’s National Conference" (PDF). Huntington Society of Canada.
  54. ↑ "Carroll receives HDSA Researcher of the Year award | Western Today". westerntoday.wwu.edu. Retrieved 2016-03-31.
  55. ↑ "Watch The Inheritance Online | Vimeo On Demand". Vimeo. Retrieved 2016-03-31.
  56. ↑ "Edward Wild". IMDb. Retrieved 4 May 2016.
  57. ↑ "Access to Understanding Science Writing Competion 2015" (PDF). Access to Understanding. Europe PubMed Central.
  58. ↑ "Huntington's And Immunity - Dr Ed Wild, University College London - The Naked Scientists". www.thenakedscientists.com. Retrieved 2016-04-01.

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