Edward Jenner

Edward Jenner

Edward Jenner by James Northcote
Born 17 May 1749
Berkeley, Gloucestershire
Died 26 January 1823(1823-01-26) (aged 73)
Berkeley, Gloucestershire
Residence Berkeley, Gloucestershire
Nationality English
Fields Medicine/surgery, natural history
Alma mater
Academic advisors John Hunter
Known for Smallpox vaccine; Vaccination

Edward Jenner, FRS (/ˈdʒɛnər/; 17 May 1749 – 26 January 1823) was an English physician and scientist who was the pioneer of smallpox vaccine, the world's first vaccine.[1][2] He is often called "the father of immunology", and his work is said to have "saved more lives than the work of any other human".[3][4][5] A member of the Royal Society, in the field of zoology he was the first person to describe the brood parasitism of the cuckoo. In 2002, Jenner was named in the BBC's list of the 100 Greatest Britons.

Early life

Memorial to Jenner in Gloucester Cathedral

Edward Anthony Jenner was born on 17 May 1749[6] (6 May Old Style) in Berkeley, Gloucestershire, as the eighth of nine children. His father, the Reverend Stephen Jenner, was the vicar of Berkeley, so Jenner received a strong basic education.[6]

He went to school in Wotton-under-Edge and Cirencester.[6] During this time, he was inoculated for smallpox, which had a lifelong effect upon his general health.[6] At the age of 14, he was apprenticed for seven years to Mr Daniel Ludlow, a surgeon of Chipping Sodbury, South Gloucestershire, where he gained most of the experience needed to become a surgeon himself.[6]

In 1770, Jenner became apprenticed in surgery and anatomy under surgeon John Hunter and others at St George's Hospital.[7] William Osler records that Hunter gave Jenner William Harvey's advice, very famous in medical circles (and characteristic of the Age of Enlightenment), "Don't think; try."[8] Hunter remained in correspondence with Jenner over natural history and proposed him for the Royal Society. Returning to his native countryside by 1773, Jenner became a successful family doctor and surgeon, practising on dedicated premises at Berkeley.

Jenner and others formed the Fleece Medical Society or Gloucestershire Medical Society, so called because it met in the parlour of the Fleece Inn, Rodborough (in Gloucestershire), meeting to dine together and read papers on medical subjects. Jenner contributed papers on angina pectoris, ophthalmia, and cardiac valvular disease and commented on cowpox. He also belonged to a similar society which met in Alveston, near Bristol.[9]

He became a master mason 30 December 1802, in Lodge of Faith and Friendship #449. From 1812–1813, he served as worshipful master of Royal Berkeley Lodge of Faith and Friendship.[10]

Zoology

Jenner was elected fellow of the Royal Society in 1788, following his publication of a careful study of the previously misunderstood life of the nested cuckoo, a study that combined observation, experiment, and dissection.

Common cuckoo

His description of the newly hatched cuckoo, pushing its host's eggs and fledgling chicks out of the nest (contrary to existing belief that the adult cuckoo did it) was only confirmed in the 20th century,[11] when photography became available. Having observed this behaviour, Jenner demonstrated an anatomical adaptation for it—the baby cuckoo has a depression in its back, not present after 12 days of life, that enables it to cup eggs and other chicks. The adult does not remain long enough in the area to perform this task. Jenner's findings were published in Philosophical Transactions of the Royal Society in 1788.[12][13]

"The singularity of its shape is well adapted to these purposes; for, different from other newly hatched birds, its back from the scapula downwards is very broad, with a considerable depression in the middle. This depression seems formed by nature for the design of giving a more secure lodgement to the egg of the Hedge-sparrow, or its young one, when the young Cuckoo is employed in removing either of them from the nest. When it is about twelve days old, this cavity is quite filled up, and then the back assumes the shape of nestling birds in general." [14]

Jenner's nephew assisted in the study. He was born on 30 June 1737.

Marriage and human medicine

A lecturer's certificate of attendance given to Jenner. He attended many lectures on chemistry, medicine and physics.

Jenner married Catharine Kingscote (died 1815 from tuberculosis) in March 1788. He might have met her while he and other fellows were experimenting with balloons. Jenner's trial balloon descended into Kingscote Park, Gloucestershire, owned by Anthony Kingscote, one of whose daughters was Catharine.[15]

He earned his MD from the University of St Andrews in 1792. He is credited with advancing the understanding of angina pectoris.[16] In his correspondence with Heberden, he wrote, "How much the heart must suffer from the coronary arteries not being able to perform their functions."

Invention of the vaccine

Edward Jenner Advising a Farmer to Vaccinate His Family. Oil painting by an English painter, c. 1910

Inoculation was already a standard practice, but involved serious risks. In 1721, Lady Mary Wortley Montagu had imported variolation to Britain after having observed it in Istanbul. Voltaire, writing of this, estimates that at this time 60% of the population caught smallpox and 20% of the population died of it.[17] Voltaire also states that the Circassians used the inoculation from times immemorial, and the custom may have been borrowed by the Turks from the Circassians.[18]

English: The process above shows the steps taken by Edward Jenner to create vaccination. Edward Jenner, the father of vaccination, created the first vaccine for smallpox. He did this by inoculating James Phipps with cowpox, a similar virus of smallpox, to create immunity, unlike variolation, which used smallpox to create an immunity to itself.

By 1768, English physician John Fewster had realized that prior infection with cowpox rendered a person immune to smallpox.[19]

In the years following 1770, at least five investigators in England and Germany (Sevel, Jensen, Jesty 1774, Rendell, Plett 1791) successfully tested a cowpox vaccine in humans against smallpox.[20] For example, Dorset farmer Benjamin Jesty[21] successfully vaccinated and presumably induced immunity with cowpox in his wife and two children during a smallpox epidemic in 1774, but it was not until Jenner's work some 20 years later that the procedure became widely understood. Indeed, Jenner may have been aware of Jesty's procedures and success.[22]

Noting the common observation that milkmaids were generally immune to smallpox, Jenner postulated that the pus in the blisters that milkmaids received from cowpox (a disease similar to smallpox, but much less virulent) protected them from smallpox.

On 14 May 1796, Jenner tested his hypothesis by inoculating James Phipps, an eight-year-old boy who was the son of Jenner's gardener. He scraped pus from cowpox blisters on the hands of Sarah Nelmes, a milkmaid who had caught cowpox from a cow called Blossom,[23] whose hide now hangs on the wall of the St George's medical school library (now in Tooting). Phipps was the 17th case described in Jenner's first paper[24] on vaccination.

Jenner inoculated Phipps in both arms that day, subsequently producing in Phipps a fever and some uneasiness, but no full-blown infection. Later, he injected Phipps with variolous material, the routine method of immunization at that time. No disease followed. The boy was later challenged with variolous material and again showed no sign of infection.

Donald Hopkins has written, "Jenner's unique contribution was not that he inoculated a few persons with cowpox, but that he then proved [by subsequent challenges] that they were immune to smallpox. Moreover, he demonstrated that the protective cowpox pus could be effectively inoculated from person to person, not just directly from cattle.[25] Jenner successfully tested his hypothesis on 23 additional subjects.

Jenner continued his research and reported it to the Royal Society, which did not publish the initial paper. After revisions and further investigations, he published his findings on the 23 cases. Some of his conclusions were correct, some erroneous; modern microbiological and microscopic methods would make his studies easier to reproduce. The medical establishment, cautious then as now, deliberated at length over his findings before accepting them. Eventually, vaccination was accepted, and in 1840, the British government banned variolation – the use of smallpox to induce immunity – and provided vaccination using cowpox free of charge. (See Vaccination acts). The success of his discovery soon spread around Europe and, for example, was used en masse in the Spanish Balmis Expedition,[26] a three-year-long mission to the Americas, the Philippines, Macao, China, and Saint Helena Island led by Dr. Francisco Javier de Balmis with the aim of giving thousands the smallpox vaccine. The expedition was successful, and Jenner wrote, "I don’t imagine the annals of history furnish an example of philanthropy so noble, so extensive as this."

1802 caricature of Jenner vaccinating patients who feared it would make them sprout cowlike appendages.

Jenner's continuing work on vaccination prevented him from continuing his ordinary medical practice. He was supported by his colleagues and the King in petitioning Parliament, and was granted £10,000 in 1802 for his work on vaccination. In 1807, he was granted another £20,000 after the Royal College of Physicians had confirmed the widespread efficacy of vaccination.

In 1803 in London, he became president of the Jennerian Society, concerned with promoting vaccination to eradicate smallpox. The Jennerian ceased operations in 1809. In 1808, with government aid, the National Vaccine Establishment was founded, but Jenner felt dishonoured by the men selected to run it and resigned his directorship.[27] Jenner became a member of the Medical and Chirurgical Society on its founding in 1805 and presented a number of papers there. The society is now the Royal Society of Medicine. He was elected a foreign honorary member of the American Academy of Arts and Sciences in 1802.[28] In 1806, Jenner was elected a foreign member of the Royal Swedish Academy of Sciences.

Returning to London in 1811, Jenner observed a significant number of cases of smallpox after vaccination. He found that in these cases the severity of the illness was notably diminished by previous vaccination. In 1821, he was appointed physician extraordinary to King George IV, a great national honour, and was also made mayor of Berkeley and justice of the peace. He continued to investigate natural history, and in 1823, the last year of his life, he presented his "Observations on the Migration of Birds" to the Royal Society.

hair cut from Jenner's body after his death

Jenner was found in a state of apoplexy on 25 January 1823, with his right side paralysed. He never fully recovered and eventually died of an apparent stroke, his second, on 26 January 1823, aged 73. He was buried in the Jenner family vault at the Church of St. Mary's, Berkeley, Gloucestershire.[29]

Edward Jenner was survived by one son and one daughter, his elder son having died of tuberculosis at the age of 21.

His original report is in the Royal College of Surgeons (London)

Religious views

Neither fanatic nor lax,[30] Jenner was a Christian who in his personal correspondence showed himself quite spiritual; he treasured the Bible.[31] Some days before his death, he stated to a friend: "I am not surprised that men are not grateful to me; but I wonder that they are not grateful to God for the good which he has made me the instrument of conveying to my fellow creatures."[32]

Legacy

In 1979, the World Health Organization declared smallpox an eradicated disease.[33] This was the result of coordinated public health efforts by many people, but vaccination was an essential component. And although the disease was declared eradicated, some pus samples still remain in laboratories in Centers for Disease Control and Prevention in Atlanta, Georgia, in the United States, and in State Research Center of Virology and Biotechnology VECTOR in Koltsovo, Novosibirsk Oblast, Russia.

Jenner's vaccine laid the foundation for contemporary discoveries in immunology.[34] In 2002, Jenner was named in the BBC's list of the 100 Greatest Britons following a UK-wide vote.[35]

The lunar crater Jenner is named in his honour.

Dr. Jenner was recognized in popular TV show "The Walking Dead". In "TS-19", a CDC scientist is named Edwin Jenner.[36]

Monuments and buildings

Dr Jenner's House, The Chantry, Church Lane, Berkeley, Gloucestershire, England
Bronze in Kensington Gardens, London

Publications

See also

References

  1. ↑ Stefan Riedel, MD, PhD (January 2005). "Edward Jenner and the history of smallpox and vaccination" 18 (1). Baylor University Medical Center: 21–25. PMC 1200696. PMID 16200144.
  2. ↑ Baxby, Derrick. "Jenner, Edward (1749–1823)". Oxford Dictionary of National Biography. Oxford University Press. Retrieved 14 February 2014.
  3. ↑ "Edward Jenner – (1749–1823)". Sundaytimes.lk. 1 June 2008. Retrieved 28 July 2009.
  4. ↑ "History – Edward Jenner (1749–1823)". BBC. 1 November 2006. Retrieved 28 July 2009.
  5. ↑ "Edward Jenner – Smallpox and the Discovery of Vaccination". Retrieved 28 July 2009.
  6. 1 2 3 4 5 "About Edward Jenner". The Jenner Institute. Retrieved 12 January 2013.
  7. ↑ "Young Edward Jenner, Born in Berkeley". Edward Jenner Museum. Retrieved 4 September 2012.
  8. ↑ Loncarek K (April 2009). "Revolution or reformation". Croatian Medical Journal 50 (2): 195–7. doi:10.3325/cmj.2009.50.195. PMC 2681061. PMID 19399955.
  9. ↑ Papers at the Royal College of Physicians summarised at http://www.aim25.ac.uk/cgi-bin/search2?coll_id=7135&inst_id=8
  10. ↑ http://freemasonry.bcy.ca/biography/jenner_e/jenner_e.html
  11. ↑ http://www.jennermuseum.com/ej/cuckoo.shtml Archived September 23, 2009, at the Wayback Machine.
  12. ↑ Observations on the Natural History of the Cuckoo. By Mr. Edward Jenner. In a Letter to John Hunter, Esq. F. R. S Jenner, E Philosophical Transactions of the Royal Society of London (1776–1886). 1788-01-01. 78:219–237 (Text at https://archive.org/details/philtrans06624558)
  13. ↑ Cuckoo chicks evicting their nest mates: coincidental observations by Edward Jenner in England and Antoine Joseph Lottinger in France, Spencer G. Sealy and Mélanie F. Guigueno Department of Biological Sciences, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada. Archives of natural history. Volume 38, Page 220-228 DOI 10.3366/anh.2011.0030, ISSN 0260-9541, Available Online October 2011
  14. ↑ (Letter to Hunter at the Royal Society, as above)
  15. ↑ Richard B. Fisher, Edward Jenner (Andre Deutsch, 1991) 40–42
  16. ↑ Journal of the Royal College of Physicians Edinburgh 2011; 41:361–5 doi:10.4997/JRCPE.2011.416
  17. ↑ François Marie Arouet de Voltaire (1778). "Letters on the English or Lettres Philosophiques".
  18. ↑ "Voltaire on Circassian Medicine: Inoculation". Circassian World. from Voltaire (1733). The Works of Voltaire. Vol. XIX (Philosophical Letters).
  19. ↑ See:
  20. ↑ Plett PC (2006). "Peter Plett and other discoverers of cowpox vaccination before Edward Jenner" [Peter Plett and other discoverers of cowpox vaccination before Edward Jenner]. Sudhoffs Archiv (in German) 90 (2): 219–32. PMID 17338405.
  21. ↑ Hammarsten J. F.; et al. (1979). "Who discovered smallpox vaccination? Edward Jenner or Benjamin Jesty?". Transactions of the American Clinical and Climatological Association 90: 44–55. PMC 2279376. PMID 390826.
  22. ↑ Grant, John (2007). Corrupted Science: Fraud, Ideology and Politics in Science. London: Facts, Figures & Fun. p. 24. ISBN 978-1-904332-73-2.
  23. ↑ "Edward Jenner & Smallpox". The Edward Jenner Museum. Archived from the original on 28 June 2009. Retrieved 13 July 2009.
  24. ↑ An Inquiry into the Causes and Effects of the Variolae Vaccinae, Edward Jenner. Retrieved 17 November 2012
  25. ↑ Hopkins, Donald R. (2002). The greatest killer: smallpox in history, with a new introduction. Chicago: University of Chicago Press. p. 80. ISBN 978-0-226-35168-1. OCLC 49305765.
  26. ↑ Carlos Franco-Paredes, Lorena Lammoglia, and José Ignacio Santos-Preciado (2005). "The Spanish Royal Philanthropic Expedition to Bring Smallpox Vaccination to the New World and Asia in the 19th Century". Clinical Infectious Diseases (Oxford Journals) 41 (9): 1285–1289. doi:10.1086/496930.
  27. ↑ John Baron, Life of Edward Jenner (London, 1837), vol. 2, pp. 122–5.
  28. ↑ "Book of Members, 1780–2010: Chapter J" (PDF). American Academy of Arts and Sciences. Retrieved 28 July 2014.
  29. ↑ "Edward Jenner – St Mary's Church, Berkeley, Gloucestershire". Retrieved 2010-12-15.
  30. ↑ Horne, Charles F.. 1894. Dr. Edward Jenner (1749–1823) by John Timbs, F.S.A.. Gjenvick-Gjønvik Archives
  31. ↑ Baron, John, 1838. The Life of Edward Jenner ...: With Illustrations of His Doctrines, and Selections from His Correspondence, Volume 2. Henry Colburn. See pages 141, 179, 221, 282, 295, 317, 416, 447–448
  32. ↑ Nolie Mumey, Edward Jenner; 1949. Vaccination: bicentenary of the birth of Edward Jenner, Volume 1. Range Press, p. 37
  33. ↑ World Health Organization (2001). "Smallpox".
  34. ↑ "Dr. Edward Jenner and the small pox vaccination". Essortment.com. Retrieved 28 July 2009.
  35. ↑ "100 great Britons – A complete list". Daily Mail. 21 August 2002. Retrieved 2 August 2012.
  36. ↑ http://www.imdb.com/character/ch0233292/?ref_=nm_flmg_act_11
  37. ↑ Royal College of Physicians. "JENNER, Edward (1749–1750)". AIM25 Archives.
  38. ↑ St George's, University of London. "Our History".
  39. ↑ Edward Jenner. "An Inquiry Into the Causes and Effects of the Variolæ Vaccinæ, Or Cow-Pox. 1798". The Harvard Classics, 1909-1914.
  40. ↑ Edward Jenner. "Further Observations on the Variolæ Vaccinæ, or Cow-Pox. 1799". The Harvard Classics, 1909-1914.
  41. ↑ Edward Jenner. "A Continuation of Facts and Observations Relative to the Variolæ Vaccinæ, or Cow-Pox. 1800". The Harvard Classics, 1909-1914.

Further reading

External links

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