Elaine Jaffe

Elaine S. Jaffe
Photo of Elaine Jaffe
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Elain Sarkin Jaffe is a senior National Cancer Institute (NCI) investigator at the National Institutes of Health (NIH). She completed her medical education at Cornell University and the University of Pennsylvania, receiving her M.D. degree from University of Pennsylvania in 1969.[1] After an internship at Georgetown University she joined NCI as a resident anatomic pathology, and has been a senior investigator since 1974, focusing on the classification and definition of lymphomas.[2] Jaffe's early work helped to provide a much more depth understanding of the origin of lymphomas, particular her work in follicular lymphoma. Her team notably elucidated the difference between T cell and B cell lymphomas.[3]

Her lab's findings led to the development of the WHO Classification of Tumours of the Hematopoetic and Lymphoid Tissues.[4] Jaffe was the President of the Society of Hematopathology at the time that the WHO's Revised European-American Classification of Lymphoid Neoplasms (REAL) classification system was developed in 1994; the REAL classification system is now considered the gold standard in hematopathology.[5] Today, her research includes genetic and epigenetic studies aimed at understanding how B-cells become Hodgkin's lymphoma cells, particularly through the lens of the microenvironment.[2] Jaffe's research has led to improvements in cancer treatments, including disease-specific therapies and improved clinical outcomes.[6]

Early life and career development

Jaffe is the daughter of Ukrainian immigrants who fled Russia during World World I.[3] As a child in White Plains, New York, Jaffe was drawn to the sciences, particularly astronomy and geology. In an interview she states, "I fell in love with biology and decided in high school that I was going to become a doctor."[6] She completed her medical education at the University of Pennsylvania in the late 1960s, where she was one of only five women in a class of more than 100 medical students.[6]

In her second year of medical school, she met and married her husband Michael Evan Jaffe, then a law student. The family then moved to Washington, D.C., where Jaffe took a residency position at Georgetown University and worked primarily in anatomic pathology. After a year at Georgetown, Jaffe entered an NCI residency program. Dr. Jaffe's early research at NCI helped replace purely descriptive classifications with those based on immunology which helped in the development process leading to today's disease-specific therapies. Jaffe and her fellow NCI researchers showed that red blood cells coated with antibody and erythrocyte-antibody-complement (EAC) adhered to B-cell areas, proving they were lymphocytes derived from the lymphoid follicles.[6]

Honors and awards

Jaffe has served on the editorial boards of the American Journal of Pathology, the American Journal of Surgical Pathology, Blood, Cancer Research, and Modern Pathology.[6] She has also served as president of the Society for Hematopathology[6] and the United States and Canadian Academy of Pathology (USCAP) (from 1998 to 1999).[7] In 1993, Jaffe was elected a fellow of the American Association for the Advancement of Science (AAAS). In 2005 she was chair of the Medical Sciences Section of AAAS and in 2007 she was the second Anita Roberts Lecturer at the NIH.[6]Jaffe is considered one of the most-cited researchers in clinical medicine by Science Watch and was among the top 10 in oncology between 1981 and 1998.[6] She is an elected member of the Institute of Medicine.[6]

Awards

Other Pertinent Topics

References

  1. ↑ "Elain S. Jaffe, M.D.". ccr.cancer.gov. Retrieved 13 March 2015.
  2. 1 2 "Elaine S. Jaffee, MD Senior Investigator Laboratory of Pathology". ccr.cancer.gov. Retrieved 13 March 2015.
  3. 1 2 "Elaine Jaffe - Transcript Summary". pathsoc.org. National Institutes of Health. Retrieved 13 March 2015.
  4. ↑ "Lymphoma Disease Discovery and Definition". ccr.cancer.gov. Retrieved 13 March 2015.
  5. ↑ Delgado, Cynthia. "Elaine Jaffe: Hercule Poirot in a Pathological Universe". nih.gov. Retrieved 13 March 2015.
  6. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 Piana, Ronald. "Elaine Jaffe: At the forefront of clinical lymphoma biology". cancernetwork.com. Cancer Network home of the journal ONCOLOGY. Retrieved 13 March 2015.
  7. ↑ United States & Canadian Academy of Pathology. "Hall of Presidents, Elaine Sarkin Jaffe". Retrieved 15 March 2015.
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