Electrical synapse

Electrical synapse

Diagram of a gap junction
Identifiers
TH H1.00.01.1.02024
FMA 67130

Anatomical terminology

An electrical synapse is a mechanical and electrically conductive link between two neighboring neurons that is formed at a narrow gap between the pre- and postsynaptic neurons known as a gap junction. At gap junctions, such cells approach within about 3.5 nm of each other,[1] a much shorter distance than the 20- to 40-nanometer distance that separates cells at chemical synapse.[2] In many animals, electrical synapse-based systems co-exist with chemical synapses.

Compared to chemical synapses, electrical synapses conduct nerve impulses faster, but, unlike chemical synapses, they lack gain—the signal in the postsynaptic neuron is the same or smaller than that of the originating neuron. Electrical synapses are often found in neural systems that require the fastest possible response, such as defensive reflexes. An important characteristic of electrical synapses is that, most of the time, they are bidirectional (allow impulse transmission in either direction).[3] However, some gap junctions do restrict communication to only one direction.

Structure

Each gap junction (aka nexus junction) contains numerous gap junction channels that cross the membranes of both cells.[4] With a lumen diameter of about 1.2 to 2.0 nm,[2][5] the pore of a gap junction channel is wide enough to allow ions and even medium-size molecules like signaling molecules to flow from one cell to the next,[2][6] thereby connecting the two cells' cytoplasm. Thus when the membrane potential of one cell changes, ions may move through from one cell to the next, carrying positive charge with them and depolarizing the postsynaptic cell.

Gap junction funnels are composed of two hemi-channels called connexons in vertebrates, one contributed by each cell at the synapse.[2][5][7] Connexons are formed by six 7.5 nm long, four-pass membrane-spanning protein subunits called connexins, which may be identical or slightly different from one another.[5]

Effects

The simplicity of electrical synapses results in synapses that are fast, but can produce only simple behaviors compared to the more complex chemical synapses.[8]

The relative speed of electrical synapses also allows for many neurons to fire synchronously.[4][5][10] Because of the speed of transmission, electrical synapses are found in escape mechanisms and other processes that require quick responses, such as the response to danger of the sea hare Aplysia, which quickly releases large quantities of ink to obscure enemies' vision.[1]

Normally, current carried by ions could travel in either direction through this type of synapse.[2] However, sometimes the junctions are rectifying synapses,[2] containing voltage-gated ion channels that open in response to depolarization of an axon's plasma membrane, and prevent current from traveling in one of the two directions.[10] Some channels may also close in response to increased calcium (Ca2+
) or hydrogen (H+
) ion concentration, so as not to spread damage from one cell to another.[10]

There is also evidence for "plasticity" at some of these synapses—that is, that the electrical connection they establish can strengthen or weaken as a result of activity,[11] or during changes in the intracellular concentration of magnesium.[12]

Electrical synapses are present throughout the central nervous system and have been studied specifically in the neocortex, hippocampus, thalamic reticular nucleus, locus coeruleus, inferior olivary nucleus, mesencephalic nucleus of the trigeminal nerve, olfactory bulb, retina, and spinal cord of vertebrates.[13]

History

The model of a reticular network of directly interconnected cells was one of the early hypotheses for the organization of the nervous system at the beginning of the 20th century. This reticular hypothesis was considered to conflict directly with the now predominant neuron doctrine, a model in which isolated, individual neurons signal to each other chemically across synaptic gaps. These two models came into sharp contrast at the award ceremony for the 1906 Nobel Prize in Physiology or Medicine, in which the award went jointly to Camillo Golgi, a reticularist and widely recognized cell biologist, and Santiago Ramón y Cajal, the champion of the neuron doctrine and the father of modern neuroscience. Golgi delivered his Nobel lecture first, in part detailing evidence for a reticular model of the nervous system. Ramón y Cajal then took the podium and refuted Golgi's conclusions in his lecture. Modern understanding of the coexistence of chemical and electrical synapses, however, suggests that both models are physiologically significant; it could be said that the Nobel committee acted with great foresight in awarding the Prize jointly.

There was substantial debate on whether the transmission of information between neurons was chemical or electrical in the first decades of the twentieth century, but chemical synaptic transmission was seen as the only answer after Otto Loewi's demonstration of chemical communication between neurons and heart muscle. Thus, the discovery of electrical communication was surprising.

Electrical synapses were first demonstrated between escape-related giant neurons in crayfish in the late 1950s, and were later found in vertebrates.[3]

See also

References

  1. 1 2 Kandel, ER; Schwartz, JH; Jessell, TM (2000). Principles of Neural Science (4th ed.). New York: McGraw-Hill. ISBN 0-8385-7701-6.
  2. 1 2 3 4 5 6 Hormuzdi SG, Filippov MA, Mitropoulou G, Monyer H, Bruzzone R (March 2004). "Electrical synapses: a dynamic signaling system that shapes the activity of neuronal networks". Biochim. Biophys. Acta 1662 (1-2): 113–37. doi:10.1016/j.bbamem.2003.10.023. PMID 15033583.
  3. 1 2 Purves, Dale, George J. Augustine, David Fitzpatrick, William C. Hall, Anthony-Samuel LaMantia, James O. McNamara, and Leonard E. White (2008). Neuroscience. 4th ed. Sinauer Associates. pp. 85–88. ISBN 978-0-87893-697-7.
  4. 1 2 Gibson JR, Beierlein M, Connors BW (January 2005). "Functional properties of electrical synapses between inhibitory interneurons of neocortical layer 4". J. Neurophysiol. 93 (1): 467–80. doi:10.1152/jn.00520.2004. PMID 15317837.
  5. 1 2 3 4 5 Bennett MV, Zukin RS (February 2004). "Electrical coupling and neuronal synchronization in the Mammalian brain". Neuron 41 (4): 495–511. doi:10.1016/S0896-6273(04)00043-1. PMID 14980200.
  6. ↑ Kandel, Schwartz & Jessell 2000, pp. 178–180
  7. ↑ Kandel, Schwartz & Jessell 2000, p. 178
  8. ↑ Kandal, et al., Chapter 10
  9. ↑ Dr. John O'Brien || Faculty Biography || The Department of Ophthalmology and Visual Science at the University of Texas Medical School at Houston
  10. 1 2 3 Kandel, Schwartz & Jessell 2000, p. 180
  11. ↑ Activity-Dependent Long-Term Depression of Electrical Synapses, Julie S. Haas, et al., Science 334, 389 (2011); doi:10.1126/science.1207502
  12. ↑ Intracellular magnesium-dependent modulation of gap junction channels formed by neuronal connexin36, Nicolas Palacios-Prado, et al., "Journal of Neuroscience",2013 Mar 13;33(11):4741-53; doi:10.1523/JNEUROSCI.2825-12.2013
  13. ↑ Electrical synapses in the mammalian brain, Connors & Long, "Annu Rev Neurosci" 2004;27:393-418

Further reading

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