Enah/Vasp-like

Enah/Vasp-like
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1qc6​
Identifiers
Symbols	EVL ; RNB6
External IDs	MGI: 1194884 HomoloGene: 56752 GeneCards: EVL Gene
Gene ontology Molecular function • actin binding • protein binding • profilin binding • SH3 domain binding Cellular component • cytoplasm • cytosol • cytoskeleton • focal adhesion • membrane • lamellipodium Biological process • actin filament organization • cell surface receptor signaling pathway • small GTPase mediated signal transduction • nervous system development • axon guidance • actin polymerization or depolymerization • organ morphogenesis • negative regulation of epithelial cell migration • positive regulation of actin filament polymerization • protein homotetramerization • positive regulation of stress fiber assembly • negative regulation of ruffle assembly Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51466	14026
Ensembl	ENSG00000196405	ENSMUSG00000021262
UniProt	Q9UI08	P70429
RefSeq (mRNA)	NM_016337	NM_001163394
RefSeq (protein)	NP_057421	NP_001156866
Location (UCSC)	Chr 14: 99.97 – 100.14 Mb	Chr 12: 108.55 – 108.69 Mb
PubMed search

Ena/VASP-like protein is a member of the Ena/VASP family of proteins that in humans is encoded by the EVL gene.^[1][2][3]

References

1. Lambrechts A, Kwiatkowski AV, Lanier LM, Bear JE, Vandekerckhove J, Ampe C, Gertler FB (Dec 2000). "cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains". J Biol Chem 275 (46): 36143–51. doi:10.1074/jbc.M006274200. PMID 10945997.
2. Klostermann A, Lutz B, Gertler F, Behl C (Jan 2001). "The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domain". J Biol Chem 275 (50): 39647–53. doi:10.1074/jbc.M006316200. PMID 10993894.
3. "Entrez Gene: EVL Enah/Vasp-like".

Further reading

• Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Ohta S, Mineta T, Kimoto M, Tabuchi K (1997). "Differential display cloning of a novel rat cDNA (RNB6) that shows high expression in the neonatal brain revealed a member of Ena/VASP family.". Biochem. Biophys. Res. Commun. 237 (2): 307–12. doi:10.1006/bbrc.1997.7113. PMID 9268706.
• Krause M, Sechi AS, Konradt M; et al. (2000). "Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton.". J. Cell Biol. 149 (1): 181–94. doi:10.1083/jcb.149.1.181. PMC 2175102. PMID 10747096.
• Hu RM, Han ZG, Song HD; et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
• Scott MP, Zappacosta F, Kim EY; et al. (2002). "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1.". J. Biol. Chem. 277 (31): 28238–46. doi:10.1074/jbc.M202783200. PMID 12029088.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Salazar MA, Kwiatkowski AV, Pellegrini L; et al. (2004). "Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton.". J. Biol. Chem. 278 (49): 49031–43. doi:10.1074/jbc.M308104200. PMID 14506234.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Krause M, Leslie JD, Stewart M; et al. (2004). "Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics.". Dev. Cell 7 (4): 571–83. doi:10.1016/j.devcel.2004.07.024. PMID 15469845.
• Lafuente EM, van Puijenbroek AA, Krause M; et al. (2004). "RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion.". Dev. Cell 7 (4): 585–95. doi:10.1016/j.devcel.2004.07.021. PMID 15469846.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rotter B, Bournier O, Nicolas G; et al. (2005). "AlphaII-spectrin interacts with Tes and EVL, two actin-binding proteins located at cell contacts.". Biochem. J. 388 (Pt 2): 631–8. doi:10.1042/BJ20041502. PMC 1138971. PMID 15656790.
• Barzik M, Kotova TI, Higgs HN; et al. (2005). "Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins.". J. Biol. Chem. 280 (31): 28653–62. doi:10.1074/jbc.M503957200. PMC 1747414. PMID 15939738.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Bournier O, Kroviarski Y, Rotter B; et al. (2006). "Spectrin interacts with EVL (Enabled/vasodilator-stimulated phosphoprotein-like protein), a protein involved in actin polymerization.". Biol. Cell 98 (5): 279–93. doi:10.1042/BC20050024. PMID 16336193.
• Bausen M, Fuhrmann JC, Betz H, O'sullivan GA (2006). "The state of the actin cytoskeleton determines its association with gephyrin: role of ena/VASP family members.". Mol. Cell. Neurosci. 31 (2): 376–86. doi:10.1016/j.mcn.2005.11.004. PMID 16376568.