Ephedrine dehydrogenase

ephedrine dehydrogenase
Identifiers
EC number	1.5.1.18
CAS number	73508-06-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, an ephedrine dehydrogenase (EC 1.5.1.18) is an enzyme that catalyzes the chemical reaction

(-)-ephedrine + NAD⁺ $\rightleftharpoons$ (R)-2-methylimino-1-phenylpropan-1-ol + NADH + H⁺

Thus, the two substrates of this enzyme are (-)-ephedrine and NAD⁺, whereas its 3 products are (R)-2-methylimino-1-phenylpropan-1-ol, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (-)-ephedrine:NAD+ 2-oxidoreductase.

References

• Klamann E, Lingens F (1980). "Degradation of (-)-ephedrine by Pseudomonas putida. Detection of (-)-ephedrine: NAD+-oxidoreductase from Arthrobacter globiformis". Z. Naturforsch. C 35 (1–2): 80–7. PMID 7405363.