Esperamicin

Esperamicin A1
Structural formula of esperamicin A1
Ball-and-stick model of the Esperamicin A1 molecule
Identifiers
99674-26-7 YesY
ChEMBL ChEMBL449274 N
ChemSpider 4940320 YesY
Jmol interactive 3D Image
PubChem 6435576
Properties
C59H80N4O22S4
Molar mass 1,325.54 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

The esperamicins are chromoprotein enediyne antitumor antibiotics of bacterial origin. Esperamicin A1 is the most well studied compound in this class. Esperamcin A1 and the related enediyne calicheamicin are the two most potent antitumor agents known.[1] The esperamicins are extremely toxic DNA splicing compounds.

Oxygen and active oxygen-radical scavengers have no significant influence upon DNA strand breakage by esperamicin, but the cleavage of DNA by esperamicin is greatly accelerated in the presence of thiol compounds. The preferential cutting sites of esperamicin are at thymidylate residues, and the frequency of nucleobase attacked (T greater than C greater than A greater than G) is different from that of calicheamicin (C much greater than T greater than A = G), neocarzinostatin (T greater than A greater than C greater than G), or bleomycin (C greater than T greater than A greater than G).[2]

References

This article is issued from Wikipedia - version of the Tuesday, January 26, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.