Ethylmalonyl-CoA decarboxylase

Ethylmalonyl-CoA decarboxylase 1

Identifiers

ECHDC1 ; HEL-S-76; MMCD; dJ351K20.2

External IDs

OMIM: 612136 HomoloGene: 23106 GeneCards: ECHDC1 Gene

Gene ontology
Molecular function	• methylmalonyl-CoA decarboxylase activity • carboxy-lyase activity
Cellular component	• cytosol • extracellular exosome
Biological process	• metabolic process
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
127.29 – 127.34 Mb

Chr 10:
29.31 – 29.35 Mb

PubMed search

Ethylmalonyl-CoA decarboxylase

Identifiers

Databases

PDB structures

Search
PMC	articles
PubMed	articles
NCBI	proteins

Ethylmalonyl-CoA decarboxylase (EC 4.1.1.94) is an enzyme with systematic name (S)-ethylmalonyl-CoA carboxy-lyase (butanoyl-CoA-forming).^[1] This enzyme catalyses the following chemical reaction

(S)-ethylmalonyl-CoA

\rightleftharpoons

butanoyl-CoA + CO₂

The vertebrate enzyme decarboxylates ethylmalonyl-CoA.

References

↑ Linster CL, Noël G, Stroobant V, Vertommen D, Vincent MF, Bommer GT, Veiga-da-Cunha M, Van Schaftingen E (Dec 2011). "Ethylmalonyl-CoA decarboxylase, a new enzyme involved in metabolite proofreading". The Journal of Biological Chemistry 286 (50): 42992–3003. doi:10.1074/jbc.m111.281527. PMID 22016388.

External links

Ethylmalonyl-CoA decarboxylase at the US National Library of Medicine Medical Subject Headings (MeSH)

Carbon-carbon lyases (EC 4.1)

4.1.1: Carboxy-lyases	Acetoacetate decarboxylase Adenosylmethionine decarboxylase Aromatic L-amino acid decarboxylase Glutamate decarboxylase Histidine decarboxylase Lysine decarboxylase Malonyl-CoA decarboxylase Ornithine decarboxylase Oxaloacetate decarboxylase Phosphoenolpyruvate carboxykinase Phosphoenolpyruvate carboxylase Phosphoribosylaminoimidazole carboxylase Pyrophosphomevalonate decarboxylase Pyruvate decarboxylase RuBisCO Uridine monophosphate synthetase/Orotidine 5'-phosphate decarboxylase Uroporphyrinogen III decarboxylase

4.1.2: Aldehyde-lyases	Fructose-bisphosphate aldolase Aldolase A Aldolase B Aldolase C 2-hydroxyphytanoyl-CoA lyase Threonine aldolase

4.1.3: Oxo-acid-lyases	Isocitrate lyase 3-hydroxy-3-methylglutaryl-CoA lyase

4.1.99: Other	Tryptophanase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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