Ets variant 3

Ets variant 3
Identifiers
Symbols	ETV3 ; METS; PE-1; PE1; bA110J1.4
External IDs	OMIM: 164873 HomoloGene: 21085 GeneCards: ETV3 Gene
Gene ontology Molecular function • RNA polymerase II regulatory region sequence-specific DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding • molecular_function • DEAD/H-box RNA helicase binding Cellular component • nuclear chromatin • RNA polymerase II transcription repressor complex Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • biological_process • negative regulation of cell proliferation • cell differentiation • cellular response to granulocyte macrophage colony-stimulating factor stimulus Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2117	27049
Ensembl	ENSG00000117036	ENSMUSG00000003382
UniProt	P41162	Q8R4Z4
RefSeq (mRNA)	NM_001145312	NM_001083318
RefSeq (protein)	NP_001138784	NP_001076787
Location (UCSC)	Chr 1: 157.12 – 157.14 Mb	Chr 3: 87.53 – 87.54 Mb
PubMed search

Ets variant 3 is a protein that in humans is encoded by the ETV3 gene. ^[1]

References

1. "Entrez Gene: Ets variant 3". Retrieved 2014-09-11.

Further reading

• Klemsz, M; Hromas, R; Raskind, W; Bruno, E; Hoffman, R (1994). "PE-1, a novel ETS oncogene family member, localizes to chromosome 1q21-q23". Genomics 20 (2): 291–4. doi:10.1006/geno.1994.1169. PMID 8020980.
• Hester, K. D.; Verhelle, D; Escoubet-Lozach, L; Luna, R; Rose, D. W.; Glass, C. K. (2007). "Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS". Cell cycle (Georgetown, Tex.) 6 (13): 1594–604. doi:10.4161/cc.6.13.4336. PMID 17525531.
• Anney, R. J. L.; Lasky-Su, J.; ó'Dúshláine, C.; Kenny, E.; Neale, B. M.; Mulligan, A.; Franke, B.; Zhou, K.; Chen, W.; Christiansen, H.; Arias-Vásquez, A.; Banaschewski, T.; Buitelaar, J.; Ebstein, R.; Miranda, A.; Mulas, F.; Oades, R. D.; Roeyers, H.; Rothenberger, A.; Sergeant, J.; Sonuga-Barke, E.; Steinhausen, H.; Asherson, P.; Faraone, S. V.; Gill, M. (2008). "Conduct disorder and ADHD: Evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study". American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B (8): 1369–1378. doi:10.1002/ajmg.b.30871. PMID 18951430.
• Sawka-Verhelle, D; Escoubet-Lozach, L; Fong, A. L.; Hester, K. D.; Herzig, S; Lebrun, P; Glass, C. K. (2004). "PE-1/METS, an antiproliferative Ets repressor factor, is induced by CREB-1/CREM-1 during macrophage differentiation". Journal of Biological Chemistry 279 (17): 17772–84. doi:10.1074/jbc.M311991200. PMID 14754893.
• Klappacher, G. W.; Lunyak, V. V.; Sykes, D. B.; Sawka-Verhelle, D; Sage, J; Brard, G; Ngo, S. D.; Gangadharan, D; Jacks, T; Kamps, M. P.; Rose, D. W.; Rosenfeld, M. G.; Glass, C. K. (2002). "An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation". Cell 109 (2): 169–80. doi:10.1016/S0092-8674(02)00714-6. PMID 12007404.
• Mesquita, B; Lopes, P; Rodrigues, A; Pereira, D; Afonso, M; Leal, C; Henrique, R; Lind, G. E.; Jerónimo, C; Lothe, R. A.; Teixeira, M. R. (2013). "Frequent copy number gains at 1q21 and 1q32 are associated with overexpression of the ETS transcription factors ETV3 and ELF3 in breast cancer irrespective of molecular subtypes". Breast Cancer Research and Treatment 138 (1): 37–45. doi:10.1007/s10549-013-2408-2. PMID 23329352.
• El Kasmi, K. C.; Smith, A. M.; Williams, L.; Neale, G.; Panopoulos, A. D.; Watowich, S. S.; Häcker, H.; Foxwell, B. M.; Murray, P. J. (2007). "Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway". Journal of immunology (Baltimore, Md. : 1950) 179 (11): 7215–7219. doi:10.4049/jimmunol.179.11.7215. PMID 18025162.