Exosome component 8

Exosome component 8
PDB rendering based on 2nn6.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2NN6​
Identifiers
Symbols	EXOSC8 ; CIP3; EAP2; OIP2; PCH1C; RRP43; Rrp43p; bA421P11.3; p9
External IDs	OMIM: 606019 MGI: 1916889 HomoloGene: 12323 GeneCards: EXOSC8 Gene
EC number	3.1.13.-
Gene ontology Molecular function • exoribonuclease activity • protein binding • AU-rich element binding Cellular component • exosome (RNase complex) • nucleus • nucleolus • cytoplasm • cytosol Biological process • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • rRNA processing • biological_process • gene expression • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11340	69639
Ensembl	ENSG00000120699	ENSMUSG00000027752
UniProt	Q96B26	Q9D753
RefSeq (mRNA)	NM_181503	NM_001163570
RefSeq (protein)	NP_852480	NP_001157042
Location (UCSC)	Chr 13: 37 – 37.01 Mb	Chr 3: 54.73 – 54.74 Mb
PubMed search

Exosome component 8, also known as EXOSC8, is a human gene, the protein product of which is part of the exosome complex.^[1]

Interactions

Exosome component 8 has been shown to interact with:

• Exosome component 5^[2] and
• Exosome component 6.^[2]

References

1. "Entrez Gene: EXOSC8 exosome component 8".
2. Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (Nov 2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/s0022-2836(02)00947-6. PMID 12419256.

Further reading

• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/S0022-2836(02)00947-6. PMID 12419256.
• Jiang T, Altman S (2002). "A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3′→5′ exoribonuclease activity". Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5295–300. doi:10.1073/pnas.072083699. PMC 122763. PMID 11929972.
• Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". J. Mol. Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. PMID 11812149.
• Chen CY, Gherzi R, Ong SE, et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186.
• Jiang T, Altman S (2001). "Protein–protein interactions with subunits of human nuclear RNase P". Proc. Natl. Acad. Sci. U.S.A. 98 (3): 920–5. doi:10.1073/pnas.021561498. PMC 14685. PMID 11158571.
• Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome". J. Biol. Chem. 276 (9): 6177–84. doi:10.1074/jbc.M007603200. PMID 11110791.
• Williams JM, Chen GC, Zhu L, Rest RF (1998). "Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth". Mol. Microbiol. 27 (1): 171–86. doi:10.1046/j.1365-2958.1998.00670.x. PMID 9466265.