Exosome component 9

Exosome component 9
PDB rendering based on 2nn6.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2NN6​
Identifiers
Symbols	EXOSC9 ; PM/Scl-75; PMSCL1; RRP45; Rrp45p; p5; p6
External IDs	OMIM: 606180 MGI: 1355319 HomoloGene: 3693 GeneCards: EXOSC9 Gene
EC number	3.1.13.-
Gene ontology Molecular function • 3'-5'-exoribonuclease activity • RNA binding • exoribonuclease activity • protein binding • AU-rich element binding • poly(A) RNA binding Cellular component • nuclear exosome (RNase complex) • exosome (RNase complex) • nuclear chromosome • nucleus • nucleoplasm • nucleolus • cytoplasm • cytosol • intermediate filament cytoskeleton • extracellular exosome Biological process • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • nuclear-transcribed mRNA catabolic process • rRNA processing • immune response • gene expression • positive regulation of cell growth • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay • nuclear mRNA surveillance • nuclear polyadenylation-dependent rRNA catabolic process • RNA phosphodiester bond hydrolysis, exonucleolytic Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5393	50911
Ensembl	ENSG00000123737	ENSMUSG00000027714
UniProt	Q06265	Q9JHI7
RefSeq (mRNA)	NM_001034194	NM_019393
RefSeq (protein)	NP_001029366	NP_062266
Location (UCSC)	Chr 4: 121.8 – 121.82 Mb	Chr 3: 36.55 – 36.57 Mb
PubMed search

Exosome component 9, also known as EXOSC9, is a human gene, the protein product of which is part of the exosome complex and is an autoantigen is patients with certain auto immune diseases, most notably scleromyositis.^[1]

References

1. "Entrez Gene: EXOSC9 exosome component 9".

Further reading

• Alderuccio F, Chan EK, Tan EM (1991). "Molecular characterization of an autoantigen of PM-Scl in the polymyositis/scleroderma overlap syndrome: a unique and complete human cDNA encoding an apparent 75-kD acidic protein of the nucleolar complex". J. Exp. Med. 173 (4): 941–52. doi:10.1084/jem.173.4.941. PMC 2190817. PMID 2007859.
• Allmang C, Petfalski E, Podtelejnikov A, et al. (1999). "The yeast exosome and human PM–Scl are related complexes of 3′ → 5′ exonucleases". Genes Dev. 13 (16): 2148–58. doi:10.1101/gad.13.16.2148. PMC 316947. PMID 10465791.
• Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome". J. Biol. Chem. 276 (9): 6177–84. doi:10.1074/jbc.M007603200. PMID 11110791.
• Chen CY, Gherzi R, Ong SE, et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186.
• Mukherjee D, Gao M, O'Connor JP, et al. (2002). "The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements". EMBO J. 21 (1–2): 165–74. doi:10.1093/emboj/21.1.165. PMC 125812. PMID 11782436.
• Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". J. Mol. Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. PMID 11812149.
• Brouwer R, Vree Egberts WT, Hengstman GJ, et al. (2002). "Autoantibodies directed to novel components of the PM/Scl complex, the human exosome". Arthritis Res. 4 (2): 134–8. doi:10.1186/ar389. PMC 83843. PMID 11879549.
• Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/S0022-2836(02)00947-6. PMID 12419256.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2003). "The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus". J. Biol. Chem. 278 (33): 30698–704. doi:10.1074/jbc.M302488200. PMID 12788944.
• Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
• Raijmakers R, Renz M, Wiemann C, et al. (2004). "PM-Scl-75 is the main autoantigen in patients with the polymyositis/scleroderma overlap syndrome". Arthritis Rheum. 50 (2): 565–9. doi:10.1002/art.20056. PMID 14872500.
• Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Tsang HT, Connell JW, Brown SE, et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• van Dijk EL, Schilders G, Pruijn GJ (2007). "Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways". RNA 13 (7): 1027–35. doi:10.1261/rna.575107. PMC 1894934. PMID 17545563.