Exosortase
| Transmembrane exosortase (Exosortase_EpsH) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Exosortase_EpsH | ||||||||
| Pfam | PF09721 | ||||||||
| |||||||||
Exosortase refers to a family of integral membrane proteins that occur in Gram-negative bacteria and that recognize and cleave the carboxyl-terminal sorting signal PEP-CTERM.[1][2] The name derives from a predicted role analogous to sortase, despite the lack any detectable sequence homology, and a strong associate of exosortase genes with exopolysaccharide or extracellular polymeric substance biosynthesis loci. Some archaea have an archaeosortase, related to exosortase rather than to sortases. Archaeosortase A recognizes the signal PGF-CTERM, found at the C-terminus of some archaeal S-layer proteins.
References
- ↑ "Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic" 4. 2006: 29. doi:10.1186/1741-7007-4-29. PMC 1569441. PMID 16930487.
- ↑ Haft, Daniel H.; Samuel H. Payne; Jeremy D. Selengut (January 2012). "Archaeosortases and Exosortases Are Widely Distributed Systems Linking Membrane Transit with Posttranslational Modification". J. Bacteriol. 194 (1): 36–48. doi:10.1128/JB.06026-11.
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