ExPASy

ExPASy is a bioinformatics resource portal operated by the Swiss Institute of Bioinformatics (SIB) and in particular the SIB Web Team. It is an extensible and integrative portal accessing many scientific resources, databases and software tools in different areas of life sciences. Scientists can access a wide range of resources in many different domains, such as proteomics, genomics, phylogeny/evolution, systems biology, population genetics, and transcriptomics. The individual resources (databases, web-based and downloadable software tools) are hosted in a decentralised way by different groups of the SIB Swiss Institute of Bioinformatics and partner institutions. Specifically, a single web portal provides a common entry point to a wide range of resources developed and operated by many different SIB groups and external institutions. The portal features a search function across selected resources. Internally, the availability and usage of resources are monitored. The portal is aimed for both expert users and for people who are not familiar with a specific domain in life sciences: in particular, the new web interface provides visual guidance for newcomers to ExPASy.

History

Originally, ExPASy was called ExPASy (Expert Protein Analysis System) and acted as a proteomics server to analyze protein sequences and structures and two-dimensional gel electrophoresis (2-D Page electrophoresis).^[1] Among others, ExPASy references the protein sequence knowledgebase, UniProtKB/Swiss-Prot, and its computer annotated supplement, UniProtKB/Trembl.

ExPASy was the first website of the life sciences.

As of 5 April 2007, ExPASy has been consulted 1 billion times since its installation on 1 August 1993.^[2]

Notes and references

↑ Gasteiger, E.; Gattiker, A; Hoogland, C; Ivanyi, I; Appel, RD; Bairoch, A (2003). "ExPASy: The proteomics server for in-depth protein knowledge and analysis". Nucleic Acids Research 31 (13): 3784–8. doi:10.1093/nar/gkg563. PMC 168970. PMID 12824418.
↑ ExPASy: SIB Bioinformatics Resource Portal

External links

Official website

Bioinformatics

Databases	Sequence databases: GenBank, European Nucleotide Archive and DNA Data Bank of Japan Secondary databases: UniProt, database of protein sequences grouping together Swiss-Prot, TrEMBL and Protein Information Resource Other databases: Protein Data Bank, Ensembl and InterPro Specialised genomic databases: BOLD, Saccharomyces Genome Database, FlyBase, VectorBase, WormBase, PHI-base, Arabidopsis Information Resource and Zebrafish Information Network

Software	BLAST Bowtie Clustal HMMER MUSCLE SAMtools TopHat

Other	Server: ExPASy Ontology: Gene Ontology

Institutions	European Bioinformatics Institute US National Center for Biotechnology Information Swiss Institute of Bioinformatics Japanese Institute of Genetics Broad Institute Wellcome Trust Sanger Institute

List of biological databases Sequencing Sequence database Sequence alignment Molecular phylogenetics

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