FAM132A

Family with sequence similarity 132, member A
Identifiers
Symbols	FAM132A ; C1QDC2; C1QTNF12; CTRP12
External IDs	HomoloGene: 12123 GeneCards: FAM132A Gene
Gene ontology Molecular function • hormone activity Cellular component • extracellular region • extracellular space Biological process • positive regulation of insulin secretion involved in cellular response to glucose stimulus • negative regulation of gluconeogenesis • regulation of glucose import • positive regulation of glucose import • positive regulation of insulin receptor signaling pathway • negative regulation of inflammatory response • positive regulation of protein kinase B signaling Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	388581	67389
Ensembl	ENSG00000184163	ENSMUSG00000023571
UniProt	Q5T7M4	Q8R2Z0
RefSeq (mRNA)	NM_001014980	NM_026125
RefSeq (protein)	NP_001014980	NP_080401
Location (UCSC)	Chr 1: 1.24 – 1.25 Mb	Chr 4: 155.96 – 155.97 Mb
PubMed search

Family with sequence similarity 132, member A also known as adipolin is a protein that in humans is encoded by the FAM132A gene.^[1] Adipolin is an adipokine.

References

1. "Entrez Gene: Family with sequence similarity 132, member A".

Further Reading

• Wei Z, Lei X, Seldin MM, Wong GW (October 2012). "Endopeptidase cleavage generates a functionally distinct isoform of C1q/tumor necrosis factor-related protein-12 (CTRP12) with an altered oligomeric state and signaling specificity". J. Biol. Chem. 287 (43): 35804–14. doi:10.1074/jbc.M112.365965. PMID 22942287.
• Enomoto T, Ohashi K, Shibata R, Higuchi A, Maruyama S, Izumiya Y, Walsh K, Murohara T, Ouchi N (October 2011). "Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that improves glucose metabolism". J. Biol. Chem. 286 (40): 34552–8. doi:10.1074/jbc.M111.277319. PMC 3186379. PMID 21849507.
• Conde J, Scotece M, López V, Gómez R, Lago F, Pino J, Gómez-Reino JJ, Gualillo O (January 2013). "Expression and modulation of adipolin/C1qdc2: a novel adipokine in human and murine ATDC-5 chondrocyte cell line". Ann. Rheum. Dis. 72 (1): 140–2. doi:10.1136/annrheumdis-2012-201693. PMID 22736092.