FAM3C

Family with sequence similarity 3, member C
Identifiers
Symbols	FAM3C ; GS3786; ILEI
External IDs	OMIM: 608618 MGI: 107892 HomoloGene: 8926 GeneCards: FAM3C Gene
Gene ontology Molecular function • cytokine activity • protein binding Cellular component • extracellular region • Golgi apparatus • cytoplasmic membrane-bounded vesicle • extracellular exosome Biological process • multicellular organismal development • biological_process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10447	27999
Ensembl	ENSG00000196937	ENSMUSG00000029672
UniProt	Q92520	Q91VU0
RefSeq (mRNA)	NM_001040020	NM_138587
RefSeq (protein)	NP_001035109	NP_613053
Location (UCSC)	Chr 7: 121.35 – 121.4 Mb	Chr 6: 22.31 – 22.36 Mb
PubMed search

Protein FAM3C is a protein that in humans is encoded by the FAM3C gene.^[1][2]

Function

This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. Alternate transcriptional splice variants which encode the same protein have been characterized.^[2]

References

1. Zhu Y, Xu G, Patel A, McLaughlin MM, Silverman C, Knecht K, Sweitzer S, Li X, McDonnell P, Mirabile R, Zimmerman D, Boyce R, Tierney LA, Hu E, Livi GP, Wolf B, Abdel-Meguid SS, Rose GD, Aurora R, Hensley P, Briggs M, Young PR (Aug 2002). "Cloning, expression, and initial characterization of a novel cytokine-like gene family". Genomics 80 (2): 144–50. doi:10.1006/geno.2002.6816. PMID 12160727.
2. "Entrez Gene: FAM3C family with sequence similarity 3, member C".

Further reading

• "Toward a complete human genome sequence.". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Fortna A, Kim Y, MacLaren E, et al. (2006). "Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution". PLoS Biol. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMC 449870. PMID 15252450.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Mauri P, Scarpa A, Nascimbeni AC, et al. (2006). "Identification of proteins released by pancreatic cancer cells by multidimensional protein identification technology: a strategy for identification of novel cancer markers". FASEB J. 19 (9): 1125–7. doi:10.1096/fj.04-3000fje. PMID 15985535.
• Grønborg M, Kristiansen TZ, Iwahori A, et al. (2006). "Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach". Mol. Cell Proteomics 5 (1): 157–71. doi:10.1074/mcp.M500178-MCP200. PMID 16215274.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Guo J, Cheng H, Zhao S, Yu L (2006). "GG: a domain involved in phage LTF apparatus and implicated in human MEB and non-syndromic hearing loss diseases". FEBS Lett. 580 (2): 581–4. doi:10.1016/j.febslet.2005.12.076. PMID 16406369.
• Waerner T, Alacakaptan M, Tamir I, et al. (2006). "ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells". Cancer Cell 10 (3): 227–39. doi:10.1016/j.ccr.2006.07.020. PMID 16959614.