FARP1

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4H6Y​
Identifiers
Symbols	FARP1 ; CDEP; FARP1-IT1; PLEKHC2; PPP1R75
External IDs	OMIM: 602654 MGI: 2446173 HomoloGene: 38098 GeneCards: FARP1 Gene
Gene ontology Molecular function • Rho guanyl-nucleotide exchange factor activity • cytoskeletal protein binding • Rac guanyl-nucleotide exchange factor activity Cellular component • cytoplasm • cytosol • cytoskeleton • cell junction • filopodium • dendrite • extrinsic component of cytoplasmic side of plasma membrane • dendritic spine Biological process • synapse assembly • negative regulation of phosphatase activity • regulation of Rho protein signal transduction • positive regulation of GTPase activity • dendrite morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10160	223254
Ensembl	ENSG00000152767	ENSMUSG00000025555
UniProt	Q9Y4F1	F8VPU2
RefSeq (mRNA)	NM_001001715	NM_134082
RefSeq (protein)	NP_001001715	NP_598843
Location (UCSC)	Chr 13: 98.14 – 98.46 Mb	Chr 14: 121.04 – 121.28 Mb
PubMed search

FERM, RhoGEF and pleckstrin domain-containing protein 1 is a protein that in humans is encoded by the FARP1 gene.^[1][2]

This gene was originally isolated through subtractive hybridization due to its increased expression in differentiated chondrocytes versus dedifferentiated chondrocytes. The resulting protein contains a predicted ezrin-like domain, a Dbl homology domain, and a pleckstrin homology domain. It is believed to be a member of the band 4.1 superfamily whose members link the cytoskeleton to the cell membrane. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[2]

References

1. Koyano Y, Kawamoto T, Shen M, Yan W, Noshiro M, Fujii K, Kato Y (Jan 1998). "Molecular cloning and characterization of CDEP, a novel human protein containing the ezrin-like domain of the band 4.1 superfamily and the Dbl homology domain of Rho guanine nucleotide exchange factors". Biochem Biophys Res Commun 241 (2): 369–75. doi:10.1006/bbrc.1997.7826. PMID 9425278.
2. "Entrez Gene: FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)".

Further reading

• Zhuang B, Su YS, Sockanathan S (February 2009). "FARP1 promotes the dendritic growth of spinal motor neuron subtypes through transmembrane Semaphorin6A and PlexinA4 signaling". Neuron 61 (3): 359–72. doi:10.1016/j.neuron.2008.12.022. PMC 2654783. PMID 19217374.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Dunham A, Matthews LH, Burton J; et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I; et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

External links

• FARP1 human gene location in the UCSC Genome Browser.
• FARP1 human gene details in the UCSC Genome Browser.