FARS2

Phenylalanyl-tRNA synthetase 2, mitochondrial
Rendering based on PDB 3CMQ​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3CMQ​, 3HFV​, 3TEG​, 3TUP​
Identifiers
Symbols	FARS2 ; COXPD14; FARS1; HSPC320; PheRS; dJ520B18.2
External IDs	OMIM: 611592 MGI: 1917205 HomoloGene: 4788 ChEMBL: 2511 GeneCards: FARS2 Gene
EC number	6.1.1.20
Gene ontology Molecular function • tRNA binding • magnesium ion binding • phenylalanine-tRNA ligase activity • protein binding • ATP binding Cellular component • cytoplasm • mitochondrion • mitochondrial matrix Biological process • tRNA aminoacylation for protein translation • phenylalanyl-tRNA aminoacylation • tRNA processing • gene expression Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10667	69955
Ensembl	ENSG00000145982	ENSMUSG00000021420
UniProt	O95363	Q99M01
RefSeq (mRNA)	NM_006567	NM_001039189
RefSeq (protein)	NP_006558	NP_001034278
Location (UCSC)	Chr 6: 5.26 – 5.77 Mb	Chr 13: 36.12 – 36.54 Mb
PubMed search

Phenylalanyl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the FARS2 gene.^[1][2]

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a phenylalanine-tRNA synthetase (PheRS) localized to the mitochondrion which consists of a single polypeptide chain, unlike the (alpha-beta)2 structure of the prokaryotic and eukaryotic cytoplasmic forms of PheRS. Structure analysis and catalytic properties indicate mitochondrial PheRSs may constitute a class of PheRS distinct from the enzymes found in prokaryotes and in the eukaryotic cytoplasm.^[2]

References

1. Bullard JM, Cai YC, Demeler B, Spremulli LL (Jun 1999). "Expression and characterization of a human mitochondrial phenylalanyl-tRNA synthetase". J Mol Biol 288 (4): 567–77. doi:10.1006/jmbi.1999.2708. PMID 10329163.
2. "Entrez Gene: FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial".

Further reading

• Levin I, Kessler N, Moor N, et al. (2007). "Purification, crystallization and preliminary X-ray characterization of a human mitochondrial phenylalanyl-tRNA synthetase". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63 (Pt 9): 761–4. doi:10.1107/S1744309107038651. PMC 2376306. PMID 17768348.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.