FAU (gene)

Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2L7R​, 4V6X​, 5AJ0​
Identifiers
Symbols	FAU ; FAU1; Fub1; Fubi; MNSFbeta; RPS30; S30; asr1
External IDs	OMIM: 134690 MGI: 102547 HomoloGene: 37562 GeneCards: FAU Gene
Gene ontology Molecular function • RNA binding • structural constituent of ribosome • poly(A) RNA binding Cellular component • cellular_component • extracellular space • cytosol • small ribosomal subunit • cytosolic small ribosomal subunit Biological process • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • innate immune response in mucosa • translation • translational initiation • translational elongation • translational termination • SRP-dependent cotranslational protein targeting to membrane • biological_process • gene expression • viral process • viral life cycle • viral transcription • antibacterial humoral response • cellular protein metabolic process • defense response to Gram-positive bacterium Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2197	14109
Ensembl	ENSG00000149806	ENSMUSG00000038274
UniProt	P35544	P35545
RefSeq (mRNA)	NM_001997	NM_001160239
RefSeq (protein)	NP_001988	NP_001153711
Location (UCSC)	Chr 11: 65.12 – 65.12 Mb	Chr 19: 6.06 – 6.06 Mb
PubMed search

40S ribosomal protein S30 is a protein that in humans is encoded by the FAU gene.^[1][2]

Function

This gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV). It encodes a fusion protein consisting of the ubiquitin-like protein fubi at the N-terminus and ribosomal protein S30 at the C-terminus. It has been proposed that the fusion protein is post-translationally processed to generate free fubi and free ribosomal protein S30. Fubi is a member of the ubiquitin family, and ribosomal protein S30 belongs to the S30E family of ribosomal proteins. Whereas the function of fubi is currently unknown, ribosomal protein S30 is a component of the 40S subunit of the cytoplasmic ribosome. Pseudogenes derived from this gene are present in the genome. Similar to ribosomal protein S30, ribosomal proteins S27a and L40 are synthesized as fusion proteins with ubiquitin.^[2]

References

1. Kas K, Schoenmakers E, van de Ven W, Weber G, Nordenskjold M, Michiels L, Merregaert J, Larsson C (Oct 1993). "Assignment of the human FAU gene to a subregion of chromosome 11q13". Genomics 17 (2): 387–92. doi:10.1006/geno.1993.1337. PMID 8406491.
2. "Entrez Gene: FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived); ribosomal protein S30".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins.". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Kas K, Michiels L, Merregaert J (1992). "Genomic structure and expression of the human fau gene: encoding the ribosomal protein S30 fused to a ubiquitin-like protein". Biochem. Biophys. Res. Commun. 187 (2): 927–33. doi:10.1016/0006-291X(92)91286-Y. PMID 1326960.
• Kato S, Sekine S, Oh SW; et al. (1995). "Construction of a human full-length cDNA bank". Gene 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
• Michiels L, Van der Rauwelaert E, Van Hasselt F; et al. (1993). "fau cDNA encodes a ubiquitin-like-S30 fusion protein and is expressed as an antisense sequence in the Finkel-Biskis-Reilly murine sarcoma virus". Oncogene 8 (9): 2537–46. PMID 8395683.
• Vladimirov SN, Ivanov AV, Karpova GG; et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
• Kenmochi N, Kawaguchi T, Rozen S; et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Rossman TG, Visalli MA, Komissarova EV (2003). "fau and its ubiquitin-like domain (FUBI) transforms human osteogenic sarcoma (HOS) cells to anchorage-independence". Oncogene 22 (12): 1817–21. doi:10.1038/sj.onc.1206283. PMID 12660817.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Suzuki Y, Yamashita R, Shirota M; et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Mourtada-Maarabouni M, Kirkham L, Farzaneh F, Williams GT (2005). "Regulation of apoptosis by fau revealed by functional expression cloning and antisense expression". Oncogene 23 (58): 9419–26. doi:10.1038/sj.onc.1208048. PMID 15543234.
• Andersen JS, Lam YW, Leung AK; et al. (2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.