FBXL3

F-box and leucine-rich repeat protein 3
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4I6J​
Identifiers
Symbols	FBXL3 ; FBL3; FBL3A; FBXL3A
External IDs	OMIM: 605653 HomoloGene: 8127 GeneCards: FBXL3 Gene
Gene ontology Molecular function • ubiquitin-protein transferase activity • protein binding • ubiquitin protein ligase activity Cellular component • ubiquitin ligase complex • nucleus • nucleoplasm • cytoplasm • cytosol • SCF ubiquitin ligase complex Biological process • circadian rhythm • protein ubiquitination • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • protein destabilization • regulation of circadian rhythm • entrainment of circadian clock by photoperiod Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26224	50789
Ensembl	ENSG00000005812	ENSMUSG00000022124
UniProt	Q9UKT7	Q8C4V4
RefSeq (mRNA)	NM_012158	NM_015822
RefSeq (protein)	NP_036290	NP_056637
Location (UCSC)	Chr 13: 76.99 – 77.03 Mb	Chr 14: 103.08 – 103.1 Mb
PubMed search

F-box/LRR-repeat protein 3 is a protein that in humans is encoded by the FBXL3 gene.^[1][2]

Function

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD40 repeats, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus.^[3]

Interactions

FBXL3 has been shown to interact with SKP1A.^[4]

References

1. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
2. Chiaur DS, Murthy S, Cenciarelli C, Parks W, Loda M, Inghirami G, Demetrick D, Pagano M (Jun 2000). "Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors". Cytogenet Cell Genet 88 (3–4): 255–8. doi:10.1159/000015532. PMID 10828603.
3. "Entrez Gene: FBXL3 F-box and leucine-rich repeat protein 3".
4. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Oct 1999). "Identification of a family of human F-box proteins". Curr. Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.

Further reading