FBXW10

F-box and WD repeat domain containing 10
Identifiers
Symbols	FBXW10 ; Fbw10; HREP; SM25H2; SM2SH2
External IDs	OMIM: 611679 MGI: 3052463 HomoloGene: 32757 GeneCards: FBXW10 Gene
Gene ontology Molecular function • ligase activity Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10517	213980
Ensembl	ENSG00000171931	ENSMUSG00000090173
UniProt	Q5XX13	Q5SUS0
RefSeq (mRNA)	NM_001267585	NM_001033669
RefSeq (protein)	NP_001254514	NP_001028841
Location (UCSC)	Chr 17: 18.74 – 18.78 Mb	Chr 11: 62.85 – 62.88 Mb
PubMed search

F-box/WD repeat-containing protein 10 is a protein that in humans is encoded by the FBXW10 gene.^[1][2][3]

Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004).[supplied by OMIM]^[3]

References

1. Kennerson ML, Nassif NT, Nicholson GA (Dec 1998). "Genomic structure and physical mapping of C17orf1: a gene associated with the proximal element of the CMT1A-REP binary repeat". Genomics 53 (1): 110–2. doi:10.1006/geno.1998.5453. PMID 9787083.
2. Kennerson ML, Gordon MJ, Blair IP, Nicholson GA (Dec 1995). "Single test for two hereditary neuropathies, CMT1A and HNPP". Clin Chem 41 (10): 1534–5. PMID 7586531.
3. "Entrez Gene: FBXW10 F-box and WD repeat domain containing 10".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Jin J, Cardozo T, Lovering RC; et al. (2005). "Systematic analysis and nomenclature of mammalian F-box proteins.". Genes Dev. 18 (21): 2573–80. doi:10.1101/gad.1255304. PMC 525538. PMID 15520277.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.