FBXW2

F-box and WD repeat domain containing 2
Identifiers
Symbols FBXW2 ; FBW2; Fwd2; Md6
External IDs OMIM: 609071 MGI: 1353435 HomoloGene: 8131 GeneCards: FBXW2 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 26190 30050
Ensembl ENSG00000119402 ENSMUSG00000035949
UniProt Q9UKT8 A2AUF9
RefSeq (mRNA) NM_012164 NM_001164768
RefSeq (protein) NP_036296 NP_001158240
Location (UCSC) Chr 9:
120.75 – 120.79 Mb
Chr 2:
34.8 – 34.83 Mb
PubMed search

F-box/WD repeat-containing protein 2 is a protein that in humans is encoded by the FBXW2 gene.[1][2][3]

Function

F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.[3]

Interactions

FBXW2 has been shown to interact with SKP1A.[1]

References

  1. 1 2 Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
  2. Chiaur DS, Murthy S, Cenciarelli C, Parks W, Loda M, Inghirami G, Demetrick D, Pagano M (Jun 2000). "Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors". Cytogenet Cell Genet 88 (3–4): 255–8. doi:10.1159/000015532. PMID 10828603.
  3. 1 2 "Entrez Gene: FBXW2 F-box and WD repeat domain containing 2".

Further reading


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