FBXW5

F-box and WD repeat domain containing 5
Identifiers
Symbols FBXW5 ; Fbw5
External IDs OMIM: 609072 MGI: 1354731 HomoloGene: 8496 GeneCards: FBXW5 Gene
Orthologs
Species Human Mouse
Entrez 54461 30839
Ensembl ENSG00000159069 ENSMUSG00000015095
UniProt Q969U6 Q9QXW2
RefSeq (mRNA) NM_018998 NM_013908
RefSeq (protein) NP_061871 NP_038936
Location (UCSC) Chr 9:
136.94 – 136.94 Mb
Chr 2:
25.5 – 25.51 Mb
PubMed search

F-box/WD repeat-containing protein 5 is a protein that in humans is encoded by the FBXW5 gene.[1]

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented.[1]

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Further reading

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