FBXW8

F-box and WD repeat domain containing 8
Identifiers
Symbols	FBXW8 ; FBW6; FBW8; FBX29; FBXO29; FBXW6
External IDs	OMIM: 609073 MGI: 1923041 HomoloGene: 17731 GeneCards: FBXW8 Gene
Gene ontology Molecular function • ubiquitin-protein transferase activity • protein binding Cellular component • cytoplasm • Golgi apparatus • SCF ubiquitin ligase complex • Cul7-RING ubiquitin ligase complex • perinuclear region of cytoplasm • 3M complex Biological process • Golgi organization • cell proliferation • protein ubiquitination • positive regulation of dendrite morphogenesis • spongiotrophoblast layer development • labyrinthine layer blood vessel development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	26259	231672
Ensembl	ENSG00000174989	ENSMUSG00000032867
UniProt	Q8N3Y1	Q8BIA4
RefSeq (mRNA)	NM_012174	NM_172721
RefSeq (protein)	NP_036306	NP_766309
Location (UCSC)	Chr 12: 116.91 – 117.03 Mb	Chr 5: 118.06 – 118.16 Mb
PubMed search

F-box/WD repeat-containing protein 8 is a protein that in humans is encoded by the FBXW8 gene.^[1][2][3]

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin-protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.^[3]

References

1. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
2. Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
3. "Entrez Gene: FBXW8 F-box and WD repeat domain containing 8".

Further reading

• Tsutsumi T, Kuwabara H, Arai T; et al. (2008). "Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice.". Mol. Cell. Biol. 28 (2): 743–51. doi:10.1128/MCB.01665-07. PMC 2223430. PMID 17998335.
• Koch HB, Zhang R, Verdoodt B; et al. (2007). "Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.". Cell Cycle 6 (2): 205–17. doi:10.4161/cc.6.2.3742. PMID 17314511.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Watanabe N, Arai H, Nishihara Y; et al. (2004). "M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.". Proc. Natl. Acad. Sci. U.S.A. 101 (13): 4419–24. doi:10.1073/pnas.0307700101. PMC 384762. PMID 15070733.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Dias DC, Dolios G, Wang R, Pan ZQ (2003). "CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16601–6. doi:10.1073/pnas.252646399. PMC 139190. PMID 12481031.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.