FCGRT

Fc fragment of IgG, receptor, transporter, alpha
PDB rendering based on 1exu.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1EXU​, 3M17​, 3M1B​, 4K71​, 4N0F​, 4N0U​
Identifiers
Symbols	FCGRT ; FCRN; alpha-chain
External IDs	OMIM: 601437 MGI: 103017 HomoloGene: 3030 ChEMBL: 5966 GeneCards: FCGRT Gene
Gene ontology Molecular function • IgG receptor activity • IgG binding • beta-2-microglobulin binding • peptide antigen binding Cellular component • plasma membrane • integral component of membrane Biological process • IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor • immune response • antigen processing and presentation • Fc-gamma receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2217	14132
Ensembl	ENSG00000104870	ENSMUSG00000003420
UniProt	P55899	Q61559
RefSeq (mRNA)	NM_001136019	NM_010189
RefSeq (protein)	NP_001129491	NP_034319
Location (UCSC)	Chr 19: 49.51 – 49.53 Mb	Chr 7: 45.09 – 45.1 Mb
PubMed search

IgG receptor FcRn large subunit p51 is a protein that in humans is encoded by the FCGRT gene.^[1][2][3]

Interactions

FCGRT has been shown to interact with Human serum albumin.^[4]

References

1. Story CM, Mikulska JE, Simister NE (December 1994). "A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus". J. Exp. Med. 180 (6): 2377–81. doi:10.1084/jem.180.6.2377. PMC 2191771. PMID 7964511.
2. Kandil E, Egashira M, Miyoshi O, Niikawa N, Ishibashi T, Kasahara M, Miyosi O (July 1996). "The human gene encoding the heavy chain of the major histocompatibility complex class I-like Fc receptor (FCGRT) maps to 19q13.3". Cytogenet. Cell Genet. 73 (1-2): 97–8. doi:10.1159/000134316. PMID 8646894.
3. "Entrez Gene: FCGRT Fc fragment of IgG, receptor, transporter, alpha".
4. Chaudhury C, Mehnaz S, Robinson JM, Hayton WL, Pearl DK, Roopenian DC, Anderson CL (February 2003). "The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan". J. Exp. Med. 197 (3): 315–22. doi:10.1084/jem.20021829. PMC 2193842. PMID 12566415.

Further reading

• Dürrbaum-Landmann I, Kaltenhäuser E, Flad HD, Ernst M (1994). "HIV-1 envelope protein gp120 affects phenotype and function of monocytes in vitro". J. Leukoc. Biol. 55 (4): 545–51. PMID 8145026.
• Leach JL, Sedmak DD, Osborne JM, Rahill B, Lairmore MD, Anderson CL (1996). "Isolation from human placenta of the IgG transporter, FcRn, and localization to the syncytiotrophoblast: implications for maternal-fetal antibody transport". J. Immunol. 157 (8): 3317–22. PMID 8871627.
• Kivelä J, Parkkila S, Waheed A, Parkkila AK, Sly WS, Rajaniemi H (1997). "Secretory carbonic anhydrase isoenzyme (CA VI) in human serum". Clin. Chem. 43 (12): 2318–22. PMID 9439449.
• Vaughn DE, Bjorkman PJ (1998). "Structural basis of pH-dependent antibody binding by the neonatal Fc receptor". Structure 6 (1): 63–73. doi:10.1016/S0969-2126(98)00008-2. PMID 9493268.
• West AP, Bjorkman PJ (2000). "Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor(,)". Biochemistry 39 (32): 9698–708. doi:10.1021/bi000749m. PMID 10933786.
• Mikulska JE, Pablo L, Canel J, Simister NE (2000). "Cloning and analysis of the gene encoding the human neonatal Fc receptor". Eur. J. Immunogenet. 27 (4): 231–40. doi:10.1046/j.1365-2370.2000.00225.x. PMID 10998088.
• Zhu X, Meng G, Dickinson BL, Li X, Mizoguchi E, Miao L, Wang Y, Robert C, Wu B, Smith PD, Lencer WI, Blumberg RS (2001). "MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells". J. Immunol. 166 (5): 3266–76. doi:10.4049/jimmunol.166.5.3266. PMC 2827247. PMID 11207281.
• Ober RJ, Radu CG, Ghetie V, Ward ES (2001). "Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies". Int. Immunol. 13 (12): 1551–9. doi:10.1093/intimm/13.12.1551. PMID 11717196.
• Praetor A, Hunziker W (2002). "beta(2)-Microglobulin is important for cell surface expression and pH-dependent IgG binding of human FcRn". J. Cell. Sci. 115 (Pt 11): 2389–97. PMID 12006623.
• Claypool SM, Dickinson BL, Yoshida M, Lencer WI, Blumberg RS (2002). "Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin". J. Biol. Chem. 277 (31): 28038–50. doi:10.1074/jbc.M202367200. PMC 2825174. PMID 12023961.
• Praetor A, Jones RM, Wong WL, Hunziker W (2002). "Membrane-anchored human FcRn can oligomerize in the absence of IgG". J. Mol. Biol. 321 (2): 277–84. doi:10.1016/S0022-2836(02)00626-5. PMID 12144784.
• Shah U, Dickinson BL, Blumberg RS, Simister NE, Lencer WI, Walker WA (2003). "Distribution of the IgG Fc receptor, FcRn, in the human fetal intestine". Pediatr. Res. 53 (2): 295–301. doi:10.1203/01.pdr.0000047663.81816.e3. PMC 2819091. PMID 12538789.
• Chaudhury C, Mehnaz S, Robinson JM, Hayton WL, Pearl DK, Roopenian DC, Anderson CL (2003). "The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan". J. Exp. Med. 197 (3): 315–22. doi:10.1084/jem.20021829. PMC 2193842. PMID 12566415.
• Schilling R, Ijaz S, Davidoff M, Lee JY, Locarnini S, Williams R, Naoumov NV (2003). "Endocytosis of hepatitis B immune globulin into hepatocytes inhibits the secretion of hepatitis B virus surface antigen and virions". J. Virol. 77 (16): 8882–92. doi:10.1128/JVI.77.16.8882-8892.2003. PMC 167249. PMID 12885906.
• Zhou J, Johnson JE, Ghetie V, Ober RJ, Ward ES (2003). "Generation of mutated variants of the human form of the MHC class I-related receptor, FcRn, with increased affinity for mouse immunoglobulin G". J. Mol. Biol. 332 (4): 901–13. doi:10.1016/S0022-2836(03)00952-5. PMID 12972260.
• Cianga P, Cianga C, Cozma L, Ward ES, Carasevici E (2003). "The MHC class I related Fc receptor, FcRn, is expressed in the epithelial cells of the human mammary gland". Hum. Immunol. 64 (12): 1152–9. doi:10.1016/j.humimm.2003.08.025. PMID 14630397.
• Ober RJ, Martinez C, Vaccaro C, Zhou J, Ward ES (2004). "Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn". J. Immunol. 172 (4): 2021–9. doi:10.4049/jimmunol.172.4.2021. PMID 14764666.