FDX1L

Ferredoxin 1-like
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2Y5C
Identifiers
Symbols	FDX1L ; FDX2
External IDs	OMIM: 614585 HomoloGene: 31955 GeneCards: FDX1L Gene
Gene ontology Molecular function • protein binding • electron carrier activity • metal ion binding • 2 iron, 2 sulfur cluster binding Cellular component • mitochondrial matrix Biological process • C21-steroid hormone biosynthetic process • xenobiotic metabolic process • steroid metabolic process • sterol metabolic process • small molecule metabolic process • oxidation-reduction process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	112812	68165
Ensembl	ENSG00000267673	ENSMUSG00000079677
UniProt	Q6P4F2	Q9CPW2
RefSeq (mRNA)	NM_001031734	NM_001039824
RefSeq (protein)	NP_001026904	NP_001034913
Location (UCSC)	Chr 19: 10.31 – 10.32 Mb	Chr 9: 21.07 – 21.07 Mb
PubMed search

Ferredoxin 1-like is a protein that in humans is encoded by the FDX1L gene. ^[1]

Mutations in FDX1L cause mitochondrial myopathy .^[2]

References

1. "Entrez Gene: Ferredoxin 1-like". Retrieved 2014-04-30.
2. Spiegel, R; Saada, A; Halvardson, J; Soiferman, D; Shaag, A; Edvardson, S; Horovitz, Y; Khayat, M; Shalev, S. A.; Feuk, L; Elpeleg, O (2013). "Deleterious mutation in FDX1L gene is associated with a novel mitochondrial muscle myopathy". European Journal of Human Genetics 22 (7): 902–6. doi:10.1038/ejhg.2013.269. PMID 24281368.

Further reading

• Sheftel, A. D.; Stehling, O; Pierik, A. J.; Elsässer, H. P.; Mühlenhoff, U; Webert, H; Hobler, A; Hannemann, F; Bernhardt, R; Lill, R (2010). "Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis". Proceedings of the National Academy of Sciences 107 (26): 11775–80. doi:10.1073/pnas.1004250107. PMC 2900682. PMID 20547883.