FEZ2

Fasciculation and elongation protein zeta 2 (zygin II)
Identifiers
Symbols	FEZ2 ; HUM3CL
External IDs	OMIM: 604826 MGI: 2675856 HomoloGene: 3742 GeneCards: FEZ2 Gene
Gene ontology Molecular function • protein binding Cellular component • cellular_component Biological process • signal transduction • nervous system development • axon guidance • negative regulation of autophagosome assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9637	225020
Ensembl	ENSG00000171055	ENSMUSG00000056121
UniProt	Q9UHY8	Q6TYB5
RefSeq (mRNA)	NM_001042548	NM_001285940
RefSeq (protein)	NP_001036013	NP_001272869
Location (UCSC)	Chr 2: 36.53 – 36.65 Mb	Chr 17: 78.38 – 78.42 Mb
PubMed search

Fasciculation and elongation protein zeta-2 is a protein that in humans is encoded by the FEZ2 gene.^[1][2]

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin.^[2]

Interactions

FEZ2 has been shown to interact with Protein kinase Mζ.^[3]

References

1. Bloom L, Horvitz HR (May 1997). "The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation". Proc Natl Acad Sci U S A 94 (7): 3414–9. doi:10.1073/pnas.94.7.3414. PMC 20384. PMID 9096408.
2. "Entrez Gene: FEZ2 fasciculation and elongation protein zeta 2 (zygin II)".
3. Fujita, Toshitsugu; Ikuta Junko; Hamada Juri; Okajima Toshihide; Tatematsu Kenji; Tanizawa Katsuyuki; Kuroda Shun'ichi (Jan 2004). "Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1". Biochem. Biophys. Res. Commun. (United States) 313 (3): 738–44. doi:10.1016/j.bbrc.2003.12.006. ISSN 0006-291X. PMID 14697253.

Further reading

• Ranes-Goldberg MG, Hori T, Mohan-Peterson S, Spits H (1993). "Identification of human pre-T/NK cell-associated genes". J. Immunol. 151 (10): 5810–21. PMID 8228263.
• Kolle G, Georgas K, Holmes GP; et al. (2000). "CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis". Mech. Dev. 90 (2): 181–93. doi:10.1016/S0925-4773(99)00248-8. PMID 10642437.
• Hu RM, Han ZG, Song HD; et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Surpili MJ, Delben TM, Kobarg J (2004). "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1". Biochemistry 42 (51): 15369–76. doi:10.1021/bi034575v. PMID 14690447.
• Fujita T, Ikuta J, Hamada J; et al. (2004). "Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1". Biochem. Biophys. Res. Commun. 313 (3): 738–44. doi:10.1016/j.bbrc.2003.12.006. PMID 14697253.
• Hillier LW, Graves TA, Fulton RS; et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Assmann EM, Alborghetti MR, Camargo ME, Kobarg J (2006). "FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region". J. Biol. Chem. 281 (15): 9869–81. doi:10.1074/jbc.M513280200. PMID 16484223.