FGF10

Fibroblast growth factor 10
PDB rendering based on 1nun.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1NUN​
Identifiers
Symbol	FGF10
External IDs	OMIM: 602115 MGI: 1099809 HomoloGene: 3284 GeneCards: FGF10 Gene
Gene ontology Molecular function • fibroblast growth factor receptor binding • type 2 fibroblast growth factor receptor binding • protein binding • growth factor activity • heparin binding • chemoattractant activity Cellular component • extracellular region • extracellular space • nucleus • plasma membrane • cell surface • extracellular matrix Biological process • establishment of mitotic spindle orientation • activation of MAPK activity • angiogenesis • metanephros development • organ induction • mesonephros development • blood vessel remodeling • metanephros morphogenesis • epidermal growth factor receptor signaling pathway • determination of left/right symmetry • salivary gland development • negative regulation of cell proliferation • insulin receptor signaling pathway • fibroblast growth factor receptor signaling pathway • regulation of smoothened signaling pathway • embryonic pattern specification • epithelial cell migration • positive regulation of epithelial cell migration • positive regulation of keratinocyte proliferation • pituitary gland development • embryonic genitalia morphogenesis • thyroid gland development • otic vesicle formation • positive regulation of vascular endothelial growth factor receptor signaling pathway • pancreas development • hair follicle morphogenesis • embryonic camera-type eye development • actin cytoskeleton reorganization • positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle • response to estradiol • response to lipopolysaccharide • positive regulation of ATPase activity • lacrimal gland development • regulation of activin receptor signaling pathway • protein localization to cell surface • somatic stem cell maintenance • Fc-epsilon receptor signaling pathway • wound healing • tissue regeneration • odontogenesis of dentin-containing tooth • muscle cell fate commitment • positive regulation of MAPK cascade • keratinocyte proliferation • innate immune response • positive regulation of DNA repair • positive regulation of DNA replication • positive regulation of Notch signaling pathway • positive regulation of transcription, DNA-templated • positive regulation of mitotic cell cycle • positive regulation of transcription from RNA polymerase II promoter • positive regulation of Ras protein signal transduction • regulation of saliva secretion • neurotrophin TRK receptor signaling pathway • phosphatidylinositol-mediated signaling • positive regulation of fibroblast proliferation • spleen development • thymus development • embryonic digestive tract morphogenesis • branching morphogenesis of an epithelial tube • female genitalia morphogenesis • male genitalia morphogenesis • positive regulation of lymphocyte proliferation • epithelial cell proliferation • urothelial cell proliferation • positive regulation of urothelial cell proliferation • positive regulation of epithelial cell proliferation • positive regulation of peptidyl-tyrosine phosphorylation • white fat cell differentiation • positive chemotaxis • induction of positive chemotaxis • smooth muscle cell differentiation • positive regulation of keratinocyte migration • radial glial cell differentiation • positive regulation of epithelial cell proliferation involved in wound healing • limb bud formation • lung epithelium development • lung saccule development • bronchiole morphogenesis • bud outgrowth involved in lung branching • bud elongation involved in lung branching • mesenchymal-epithelial cell signaling involved in lung development • Type II pneumocyte differentiation • prostatic bud formation • fibroblast growth factor receptor signaling pathway involved in mammary gland specification • mammary gland bud formation • submandibular salivary gland formation • epithelial cell proliferation involved in salivary gland morphogenesis • regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling • branch elongation involved in salivary gland morphogenesis • semicircular canal fusion • mesenchymal cell differentiation involved in lung development • secretion by lung epithelial cell involved in lung growth • lung proximal/distal axis specification • tear secretion • positive regulation of white fat cell proliferation • ERK1 and ERK2 cascade • positive regulation of ERK1 and ERK2 cascade • Harderian gland development • negative regulation of cell cycle arrest • positive regulation of hair follicle cell proliferation • positive regulation of canonical Wnt signaling pathway • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2255	14165
Ensembl	ENSG00000070193	ENSMUSG00000021732
UniProt	O15520	O35565
RefSeq (mRNA)	NM_004465	NM_008002
RefSeq (protein)	NP_004456	NP_032028
Location (UCSC)	Chr 5: 44.3 – 44.39 Mb	Chr 13: 118.67 – 118.79 Mb
PubMed search

Fibroblast growth factor 10 is a protein that in humans is encoded by the FGF10 gene.^[1][2]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of limb bud formation. This gene is also implicated to be a primary factor in the process of wound healing.^[2]

References

1. Emoto H, Tagashira S, Mattei MG, Yamasaki M, Hashimoto G, Katsumata T, Negoro T, Nakatsuka M, Birnbaum D, Coulier F, Itoh N (Oct 1997). "Structure and expression of human fibroblast growth factor-10". J Biol Chem 272 (37): 23191–4. doi:10.1074/jbc.272.37.23191. PMID 9287324.
2. "Entrez Gene: FGF10 fibroblast growth factor 10".

Further reading

• Igarashi M, Finch PW, Aaronson SA (1998). "Characterization of recombinant human fibroblast growth factor (FGF)-10 reveals functional similarities with keratinocyte growth factor (FGF-7).". J. Biol. Chem. 273 (21): 13230–5. doi:10.1074/jbc.273.21.13230. PMID 9582367.
• Sekine K, Ohuchi H, Fujiwara M; et al. (1999). "Fgf10 is essential for limb and lung formation.". Nat. Genet. 21 (1): 138–41. doi:10.1038/5096. PMID 9916808.
• Jimenez PA, Rampy MA (1999). "Keratinocyte growth factor-2 accelerates wound healing in incisional wounds.". J. Surg. Res. 81 (2): 238–42. doi:10.1006/jsre.1998.5501. PMID 9927546.
• Ropiquet F, Giri D, Kwabi-Addo B; et al. (2000). "FGF-10 is expressed at low levels in the human prostate.". Prostate 44 (4): 334–8. doi:10.1002/1097-0045(20000901)44:4<334::AID-PROS11>3.0.CO;2-G. PMID 10951499.
• Marchese C, Felici A, Visco V; et al. (2001). "Fibroblast growth factor 10 induces proliferation and differentiation of human primary cultured keratinocytes.". J. Invest. Dermatol. 116 (4): 623–8. doi:10.1046/j.0022-202x.2001.01280.x. PMID 11286634.
• Bagai S, Rubio E, Cheng JF; et al. (2002). "Fibroblast growth factor-10 is a mitogen for urothelial cells.". J. Biol. Chem. 277 (26): 23828–37. doi:10.1074/jbc.M201658200. PMID 11923311.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yeh BK, Igarashi M, Eliseenkova AV; et al. (2003). "Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors.". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2266–71. doi:10.1073/pnas.0436500100. PMC 151329. PMID 12591959.
• Upadhyay D, Lecuona E, Comellas A; et al. (2003). "Fibroblast growth factor-10 upregulates Na,K-ATPase via the MAPK pathway.". FEBS Lett. 545 (2-3): 173–6. doi:10.1016/S0014-5793(03)00527-1. PMID 12804770.
• Izvolsky KI, Zhong L, Wei L; et al. (2003). "Heparan sulfates expressed in the distal lung are required for Fgf10 binding to the epithelium and for airway branching.". Am. J. Physiol. Lung Cell Mol. Physiol. 285 (4): L838–46. doi:10.1152/ajplung.00081.2003. PMID 12818887.
• Tomlinson DC, Grindley JC, Thomson AA (2004). "Regulation of Fgf10 gene expression in the prostate: identification of transforming growth factor-beta1 and promoter elements.". Endocrinology 145 (4): 1988–95. doi:10.1210/en.2003-0842. PMID 14726452.
• Upadhyay D, Bundesmann M, Panduri V; et al. (2004). "Fibroblast growth factor-10 attenuates H2O2-induced alveolar epithelial cell DNA damage: role of MAPK activation and DNA repair.". Am. J. Respir. Cell Mol. Biol. 31 (1): 107–13. doi:10.1165/rcmb.2003-0064OC. PMID 14975937.
• Theodorou V, Boer M, Weigelt B; et al. (2005). "Fgf10 is an oncogene activated by MMTV insertional mutagenesis in mouse mammary tumors and overexpressed in a subset of human breast carcinomas.". Oncogene 23 (36): 6047–55. doi:10.1038/sj.onc.1207816. PMID 15208658.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ibrahimi OA, Yeh BK, Eliseenkova AV; et al. (2005). "Analysis of mutations in fibroblast growth factor (FGF) and a pathogenic mutation in FGF receptor (FGFR) provides direct evidence for the symmetric two-end model for FGFR dimerization.". Mol. Cell. Biol. 25 (2): 671–84. doi:10.1128/MCB.25.2.671-684.2005. PMC 543411. PMID 15632068.
• Entesarian M, Matsson H, Klar J; et al. (2005). "Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands.". Nat. Genet. 37 (2): 125–7. doi:10.1038/ng1507. PMID 15654336.
• Kovacs D, Falchi M, Cardinali G; et al. (2005). "Immunohistochemical analysis of keratinocyte growth factor and fibroblast growth factor 10 expression in psoriasis.". Exp. Dermatol. 14 (2): 130–7. doi:10.1111/j.0906-6705.2005.00261.x. PMID 15679583.
• Ye F, Duvillié B, Scharfmann R (2005). "Fibroblast growth factors 7 and 10 are expressed in the human embryonic pancreatic mesenchyme and promote the proliferation of embryonic pancreatic epithelial cells.". Diabetologia 48 (2): 277–81. doi:10.1007/s00125-004-1638-6. PMID 15690149.
• Beer HD, Bittner M, Niklaus G; et al. (2005). "The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair.". Oncogene 24 (34): 5269–77. doi:10.1038/sj.onc.1208560. PMID 15806171.

External links

• OMIM entry on aplasia of lacrimal and salivary glands