FGFBP1

Fibroblast growth factor binding protein 1
Identifiers
Symbols	FGFBP1 ; FGF-BP; FGF-BP1; FGFBP; FGFBP-1; HBP17
External IDs	OMIM: 607737 MGI: 1096350 HomoloGene: 3766 GeneCards: FGFBP1 Gene
Gene ontology Molecular function • protein binding • heparin binding • growth factor binding Cellular component • extracellular space • plasma membrane Biological process • positive regulation of defense response to virus by host • signal transduction • cell-cell signaling • negative regulation of cell proliferation • activation of mitophagy in response to mitochondrial depolarization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9982	14181
Ensembl	ENSG00000137440	ENSMUSG00000048373
UniProt	Q14512	O70514
RefSeq (mRNA)	NM_005130	NM_001271616
RefSeq (protein)	NP_005121	NP_001258545
Location (UCSC)	Chr 4: 15.94 – 15.94 Mb	Chr 5: 43.98 – 43.98 Mb
PubMed search

Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene.^[1][2][3]

FGFBP1, or HBP17, binds to both acidic (FGF1; MIM 131220) and basic (FGF2; MIM 134920) fibroblast growth factors in a reversible manner. It also binds to perlecan (HSPG2; MIM 142461).[supplied by OMIM]^[3]

Interactions

FGFBP1 has been shown to interact with Perlecan.^[1]

References

1. Mongiat M, Otto J, Oldershaw R, Ferrer F, Sato JD, Iozzo RV (Mar 2001). "Fibroblast growth factor-binding protein is a novel partner for perlecan protein core". J Biol Chem 276 (13): 10263–71. doi:10.1074/jbc.M011493200. PMID 11148217.
2. Wu DQ, Kan MK, Sato GH, Okamoto T, Sato JD (Oct 1991). "Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors". J Biol Chem 266 (25): 16778–85. PMID 1885605.
3. "Entrez Gene: FGFBP1 fibroblast growth factor binding protein 1".

Further reading

• Abuharbeid S, Czubayko F, Aigner A (2006). "The fibroblast growth factor-binding protein FGF-BP.". Int. J. Biochem. Cell Biol. 38 (9): 1463–8. doi:10.1016/j.biocel.2005.10.017. PMID 16324873.
• Lange LG, Sytkowski AJ, Vallee BL (1976). "Human liver alcohol dehydrogenase: purification, composition, and catalytic features.". Biochemistry 15 (21): 4687–93. doi:10.1021/bi00666a023. PMID 9982.
• Czubayko F, Liaudet-Coopman ED, Aigner A; et al. (1997). "A secreted FGF-binding protein can serve as the angiogenic switch in human cancer.". Nat. Med. 3 (10): 1137–40. doi:10.1038/nm1097-1137. PMID 9334727.
• Wang XC, Chen JH, Crab JW, Sato JD (1998). "Purification of heparin-binding protein HBp17 and identification of HBp17 heparin binding site.". Biochem. Mol. Biol. Int. 46 (1): 81–7. doi:10.1080/15216549800203582. PMID 9784842.
• Harris VK, Coticchia CM, Kagan BL; et al. (2000). "Induction of the angiogenic modulator fibroblast growth factor-binding protein by epidermal growth factor is mediated through both MEK/ERK and p38 signal transduction pathways.". J. Biol. Chem. 275 (15): 10802–11. doi:10.1074/jbc.275.15.10802. PMID 10753873.
• Sauter ER, Nesbit M, Tichansky D; et al. (2001). "Fibroblast growth factor-binding protein expression changes with disease progression in clinical and experimental human squamous epithelium.". Int. J. Cancer 92 (3): 374–81. doi:10.1002/ijc.1207. PMID 11291074.
• Chen JH, Wang XC, Sato JD (2001). "Bifunctional effects of heparin-binding protein HBp17 on DNA synthesis in cells.". Cell Biol. Int. 25 (6): 567–70. doi:10.1006/cbir.2000.0688. PMID 11407864.
• Tassi E, Al-Attar A, Aigner A; et al. (2001). "Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein.". J. Biol. Chem. 276 (43): 40247–53. doi:10.1074/jbc.M104933200. PMID 11509569.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Beer HD, Bittner M, Niklaus G; et al. (2005). "The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair.". Oncogene 24 (34): 5269–77. doi:10.1038/sj.onc.1208560. PMID 15806171.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Xie B, Tassi E, Swift MR; et al. (2006). "Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display.". J. Biol. Chem. 281 (2): 1137–44. doi:10.1074/jbc.M510754200. PMID 16257968.
• Ray PE, Tassi E, Liu XH, Wellstein A (2006). "Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndrome.". Am. J. Physiol. Regul. Integr. Comp. Physiol. 290 (1): R105–13. doi:10.1152/ajpregu.00492.2005. PMID 16352855.
• Lim J, Hao T, Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.