FGFR1OP

FGFR1 oncogene partner
PDB rendering based on 2d68.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2D68​
Identifiers
Symbols	FGFR1OP ; FOP
External IDs	OMIM: 605392 MGI: 1922546 HomoloGene: 5116 GeneCards: FGFR1OP Gene
Gene ontology Molecular function • protein tyrosine kinase activity • protein binding • protein kinase binding • protein tyrosine kinase inhibitor activity • protein homodimerization activity Cellular component • nucleus • centrosome • cytosol • perinuclear region of cytoplasm Biological process • G2/M transition of mitotic cell cycle • mitotic cell cycle • negative regulation of protein kinase activity • organelle organization • positive regulation of cell proliferation • peptidyl-tyrosine phosphorylation • positive regulation of cell growth • positive regulation of cell migration • microtubule anchoring • negative regulation of protein tyrosine kinase activity Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11116	75296
Ensembl	ENSG00000213066	ENSMUSG00000069135
UniProt	O95684	Q66JX5
RefSeq (mRNA)	NM_001278690	NM_001197046
RefSeq (protein)	NP_001265619	NP_001183975
Location (UCSC)	Chr 6: 167 – 167.05 Mb	Chr 17: 8.17 – 8.2 Mb
PubMed search

FGFR1 oncogene partner is a protein that in humans is encoded by the FGFR1OP gene.^[1][2][3]

This gene encodes a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified.^[3]

References

1. Popovici C, Zhang B, Gregoire MJ, Jonveaux P, Lafage-Pochitaloff M, Birnbaum D, Pebusque MJ (Mar 1999). "The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1". Blood 93 (4): 1381–9. PMID 9949182.
2. Reither A, Hehlmann R, Goldman JM, Cross NC (Aug 1999). "[The 8p11 myeloproliferative syndrome]". Med Klin (Munich) 94 (4): 207–10. PMID 10373756.
3. "Entrez Gene: FGFR1OP FGFR1 oncogene partner".

Further reading

• Guasch G, Ollendorff V, Borg JP; et al. (2001). "8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways.". Mol. Cell. Biol. 21 (23): 8129–42. doi:10.1128/MCB.21.23.8129-8142.2001. PMC 99978. PMID 11689702.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Guasch G, Delaval B, Arnoulet C; et al. (2004). "FOP-FGFR1 tyrosine kinase, the product of a t(6;8) translocation, induces a fatal myeloproliferative disease in mice.". Blood 103 (1): 309–12. doi:10.1182/blood-2003-05-1690. PMID 12969958.
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Andersen JS, Wilkinson CJ, Mayor T; et al. (2003). "Proteomic characterization of the human centrosome by protein correlation profiling.". Nature 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843.
• Brill LM, Salomon AR, Ficarro SB; et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yan X, Habedanck R, Nigg EA (2006). "A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring.". Mol. Biol. Cell 17 (2): 634–44. doi:10.1091/mbc.E05-08-0810. PMC 1356575. PMID 16314388.
• Mikolajka A, Yan X, Popowicz GM; et al. (2006). "Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization.". J. Mol. Biol. 359 (4): 863–75. doi:10.1016/j.jmb.2006.03.070. PMID 16690081.
• Mano Y, Takahashi K, Ishikawa N; et al. (2007). "Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer.". Cancer Sci. 98 (12): 1902–13. doi:10.1111/j.1349-7006.2007.00610.x. PMID 17888034.