Fibroblast growth factor receptor-like 1

Fibroblast growth factor receptor-like 1
Identifiers
Symbols	FGFRL1 ; FGFR5; FHFR
External IDs	OMIM: 605830 MGI: 2150920 HomoloGene: 11067 GeneCards: FGFRL1 Gene
EC number	3.2.1.76
Gene ontology Molecular function • fibroblast growth factor-activated receptor activity • heparin binding • fibroblast growth factor binding Cellular component • Golgi apparatus • plasma membrane • integral component of membrane • transport vesicle • cell-cell contact zone Biological process • skeletal system development • heart valve morphogenesis • negative regulation of cell proliferation • fibroblast growth factor receptor signaling pathway • substrate adhesion-dependent cell spreading • protein homooligomerization • protein heterooligomerization • ventricular septum morphogenesis • diaphragm development • cell-cell adhesion via plasma-membrane adhesion molecules Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	53834	116701
Ensembl	ENSG00000127418	ENSMUSG00000008090
UniProt	Q8N441	Q91V87
RefSeq (mRNA)	NM_001004356	NM_001164259
RefSeq (protein)	NP_001004356	NP_001157731
Location (UCSC)	Chr 4: 1.01 – 1.03 Mb	Chr 5: 108.69 – 108.71 Mb
PubMed search

Fibroblast growth factor receptor-like 1 is a protein that in humans is encoded by the FGFRL1 gene.^[1]

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene.^[1]

References

1. "Entrez Gene: FGFRL1 fibroblast growth factor receptor-like 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Wiedemann M, Trueb B (2001). "Characterization of a novel protein (FGFRL1) from human cartilage related to FGF receptors". Genomics 69 (2): 275–279. doi:10.1006/geno.2000.6332. PMID 11031111.
• Kim I, Moon S, Yu K, et al. (2001). "A novel fibroblast growth factor receptor-5 preferentially expressed in the pancreas(1)". Biochim. Biophys. Acta 1518 (1–2): 152–6. doi:10.1016/s0167-4781(00)00282-7. PMID 11267671.
• Sleeman M, Fraser J, McDonald M, et al. (2001). "Identification of a new fibroblast growth factor receptor, FGFR5". Gene 271 (2): 171–182. doi:10.1016/S0378-1119(01)00518-2. PMID 11418238.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Trueb B, Zhuang L, Taeschler S, Wiedemann M (2003). "Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues". J. Biol. Chem. 278 (36): 33857–33865. doi:10.1074/jbc.M300281200. PMID 12813049.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–2824. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Antoine M, Wirz W, Tag CG, et al. (2005). "Expression pattern of fibroblast growth factors (FGFs), their receptors and antagonists in primary endothelial cells and vascular smooth muscle cells". Growth Factors 23 (2): 87–95. doi:10.1080/08977190500096004. PMID 16019430.
• Schild C, Trueb B (2006). "Aberrant expression of FGFRL1, a novel FGF receptor, in ovarian tumors". Int. J. Mol. Med. 16 (6): 1169–73. doi:10.3892/ijmm.16.6.1169. PMID 16273302.