FIBP
| Fibroblast growth factor (acidic) intracellular binding protein | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | FIBP ; FGFIBP; FIBP-1 | ||||||||||||
| External IDs | OMIM: 608296 MGI: 1926233 HomoloGene: 3106 GeneCards: FIBP Gene | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
 | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9158 | 58249 | |||||||||||
| Ensembl | ENSG00000172500 | ENSMUSG00000024911 | |||||||||||
| UniProt | O43427 | Q9JI19 | |||||||||||
| RefSeq (mRNA) | NM_004214 | NM_001253832 | |||||||||||
| RefSeq (protein) | NP_004205 | NP_001240761 | |||||||||||
| Location (UCSC) |
Chr 11: 65.88 – 65.89 Mb |
Chr 19: 5.46 – 5.47 Mb | |||||||||||
| PubMed search | |||||||||||||
Acidic fibroblast growth factor intracellular-binding protein is a protein that in humans is encoded by the FIBP gene.[1][2]
Function
Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene.[2]
Interactions
FIBP has been shown to interact with FGF1.[1]
References
- 1 2 Kolpakova, E; Wiedłocha, A; Stenmark, H; Klingenberg, O; Faines, PO; Olsnes, S (15 November 1998). "Cloning of an intracellular protein that binds selectively to mitogenic acidic fibroblast growth factor". Biochem. J. 336 ( Pt 1) (1): 213–22. PMC 1219860. PMID 9806903. Retrieved October 21, 2015.
- 1 2 "Entrez Gene: FIBP fibroblast growth factor (acidic) intracellular binding protein".
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Kolpakova E, Frengen E, Stokke T, Olsnes S (2000). "Organization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding protein". Biochem. J. 352 Pt 3 (3): 629–35. doi:10.1042/0264-6021:3520629. PMC 1221498. PMID 11104667.
- Tassi E, Al-Attar A, Aigner A, Swift MR, McDonnell K, Karavanov A, Wellstein A (2001). "Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein". J. Biol. Chem. 276 (43): 40247–53. doi:10.1074/jbc.M104933200. PMID 11509569.
- Skjerpen CS, Nilsen T, Wesche J, Olsnes S (2002). "Binding of FGF-1 variants to protein kinase CK2 correlates with mitogenicity". EMBO J. 21 (15): 4058–69. doi:10.1093/emboj/cdf402. PMC 126148. PMID 12145206.
- Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
This article is issued from Wikipedia - version of the Saturday, January 30, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.