FIP1L1

Factor interacting with PAPOLA and CPSF1
Identifiers
Symbols	FIP1L1 ; FIP1; Rhe; hFip1
External IDs	OMIM: 607686 MGI: 1914149 HomoloGene: 134000 GeneCards: FIP1L1 Gene
Gene ontology Molecular function • protein binding • poly(A) RNA binding Cellular component • nucleoplasm • mRNA cleavage and polyadenylation specificity factor complex Biological process • mRNA processing Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	81608	66899
Ensembl	ENSG00000145216	ENSMUSG00000029227
UniProt	Q6UN15	Q9D824
RefSeq (mRNA)	NM_001134937	NM_001159573
RefSeq (protein)	NP_001128409	NP_001153045
Location (UCSC)	Chr 4: 53.38 – 53.46 Mb	Chr 5: 74.54 – 74.6 Mb
PubMed search

Pre-mRNA 3'-end-processing factor FIP1 is a protein that in humans is encoded by the FIP1L1 gene.^[1][2]

References

1. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
2. "Entrez Gene: FIP1L1 FIP1 like 1 (S. cerevisiae)".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cools J, DeAngelo DJ, Gotlib J; et al. (2003). "A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome.". N. Engl. J. Med. 348 (13): 1201–14. doi:10.1056/NEJMoa025217. PMID 12660384.
• Griffin JH, Leung J, Bruner RJ; et al. (2003). "Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome.". Proc. Natl. Acad. Sci. U.S.A. 100 (13): 7830–5. doi:10.1073/pnas.0932698100. PMC 164673. PMID 12808148.
• Pardanani A, Ketterling RP, Brockman SR; et al. (2004). "CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy.". Blood 102 (9): 3093–6. doi:10.1182/blood-2003-05-1627. PMID 12842979.
• Cools J, Quentmeier H, Huntly BJ; et al. (2004). "The EOL-1 cell line as an in vitro model for the study of FIP1L1-PDGFRA-positive chronic eosinophilic leukemia.". Blood 103 (7): 2802–5. doi:10.1182/blood-2003-07-2479. PMID 14630792.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Sakashita E, Tatsumi S, Werner D; et al. (2004). "Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo.". Mol. Cell. Biol. 24 (3): 1174–87. doi:10.1128/MCB.24.3.1174-1187.2004. PMC 321435. PMID 14729963.
• Kaufmann I, Martin G, Friedlein A; et al. (2005). "Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase.". EMBO J. 23 (3): 616–26. doi:10.1038/sj.emboj.7600070. PMC 1271804. PMID 14749727.
• Pardanani A, Brockman SR, Paternoster SF; et al. (2004). "FIP1L1-PDGFRA fusion: prevalence and clinicopathologic correlates in 89 consecutive patients with moderate to severe eosinophilia.". Blood 104 (10): 3038–45. doi:10.1182/blood-2004-03-0787. PMID 15284118.
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Zhao X, Oberg D, Rush M; et al. (2005). "A 57-nucleotide upstream early polyadenylation element in human papillomavirus type 16 interacts with hFip1, CstF-64, hnRNP C1/C2, and polypyrimidine tract binding protein.". J. Virol. 79 (7): 4270–88. doi:10.1128/JVI.79.7.4270-4288.2005. PMC 1061554. PMID 15767428.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Mehrle A, Rosenfelder H, Schupp I; et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Cools J, Stover EH, Gilliland DG (2006). "Detection of the FIP1L1-PDGFRA fusion in idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia.". Methods Mol. Med. 125: 177–87. doi:10.1385/1-59745-017-0:177. PMID 16502585.
• Stover EH, Chen J, Folens C; et al. (2006). "Activation of FIP1L1-PDGFRalpha requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent.". Proc. Natl. Acad. Sci. U.S.A. 103 (21): 8078–83. doi:10.1073/pnas.0601192103. PMC 1472432. PMID 16690743.
• Beausoleil SA, Villén J, Gerber SA; et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.