FKBP7

FK506 binding protein 7 is a protein that in humans is encoded by the FKBP7 gene.[1] The gene is also known as FKBP23 and PPIase.[1] FKBP7 belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. Members of this family exhibit PPIase activity and function as molecular chaperones. The orthologous protein in mouse is located in the endoplasmic reticulum and binds calcium.[1][2]

Model organisms

Model organisms have been used in the study of FKBP7 function. A conditional knockout mouse line, called Fkbp7tm2a(KOMP)Wtsi[3][4] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[5][6][7]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[8][9]

Twenty three tests were carried out on mutant mice, but no significant abnormalities were observed.[8]

References

  1. 1 2 3 "FK506 binding protein 7". Retrieved 2011-12-06.
  2. ↑ Nakamura, T.; Yabe, D.; Kanazawa, N.; Tashiro, K.; Sasayama, S.; Honjo, T. (1998). "Molecular Cloning, Characterization, and Chromosomal Localization of FKBP23, a Novel FK506-Binding Protein with Ca2+-Binding Ability". Genomics 54 (1): 89–98. doi:10.1006/geno.1998.5571. PMID 9806833.
  3. ↑ "International Knockout Mouse Consortium".
  4. ↑ "Mouse Genome Informatics".
  5. ↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  6. ↑ Dolgin E (June 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  7. ↑ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  8. 1 2 3 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x.
  9. ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.
  10. ↑ "Salmonella infection data for Fkbp7". Wellcome Trust Sanger Institute.
  11. ↑ "Citrobacter infection data for Fkbp7". Wellcome Trust Sanger Institute.
  12. ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.

Further reading

  • Patterson, C. E.; Gao, J.; Rooney, A. P.; Davis, E. C. (2002). "Genomic Organization of Mouse and Human 65 kDa FK506-Binding Protein Genes and Evolution of the FKBP Multigene Family". Genomics 79 (6): 881–889. doi:10.1006/geno.2002.6777. PMID 12036304. 
  • Matsuda, M.; Koide, T.; Yorihuzi, T.; Hosokawa, N.; Nagata, K. (2001). "Molecular Cloning of a Novel Ubiquitin-like Protein, UBIN, That Binds to ER Targeting Signal Sequences". Biochemical and Biophysical Research Communications 280 (2): 535–540. doi:10.1006/bbrc.2000.4149. PMID 11162551. 


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