FLRT2

Fibronectin leucine rich transmembrane protein 2
Identifiers
Symbols	FLRT2 ; KIAA0405
External IDs	OMIM: 604807 MGI: 3603594 HomoloGene: 8291 GeneCards: FLRT2 Gene
Gene ontology Molecular function • receptor signaling protein activity • protein binding, bridging • chemorepellent activity Cellular component • proteinaceous extracellular matrix • extracellular space • intracellular • integral component of plasma membrane • focal adhesion • extracellular exosome Biological process • cell adhesion • axon guidance • biological_process • intracellular signal transduction • negative chemotaxis • positive regulation of synapse assembly • regulation of neuron migration Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23768	399558
Ensembl	ENSG00000185070	ENSMUSG00000047414
UniProt	O43155	Q8BLU0
RefSeq (mRNA)	NM_013231	NM_201518
RefSeq (protein)	NP_037363	NP_958926
Location (UCSC)	Chr 14: 85.53 – 85.65 Mb	Chr 12: 95.69 – 95.79 Mb
PubMed search

Leucine-rich repeat transmembrane protein FLRT2 is a protein that in humans is encoded by the FLRT2 gene.^[1][2][3]

This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRT family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix.^[3]

References

1. Lacy SE, Bonnemann CG, Buzney EA, Kunkel LM (Mar 2000). "Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins". Genomics 62 (3): 417–26. doi:10.1006/geno.1999.6033. PMID 10644439.
2. Haines BP, Wheldon LM, Summerbell D, Heath JK, Rigby PW (Sep 2006). "Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development". Dev Biol 297 (1): 14–25. doi:10.1016/j.ydbio.2006.04.004. PMID 16872596.
3. "Entrez Gene: FLRT2 fibronectin leucine rich transmembrane protein 2".

Further reading

• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ishikawa K, Nagase T, Nakajima D; et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.