FLVCR1

Feline leukemia virus subgroup C cellular receptor 1
Identifiers
Symbols	FLVCR1 ; AXPC1; FLVCR; MFSD7B; PCA; PCARP
External IDs	OMIM: 609144 MGI: 2444881 HomoloGene: 56661 GeneCards: FLVCR1 Gene
Gene ontology Molecular function • transporter activity • protein binding • heme transporter activity Cellular component • mitochondrion • plasma membrane • integral component of plasma membrane • mitochondrial membrane Biological process • blood vessel development • in utero embryonic development • transport • mitochondrial transport • cellular iron ion homeostasis • multicellular organismal development • heme transport • erythrocyte differentiation • multicellular organism growth • embryonic digit morphogenesis • erythrocyte maturation • regulation of organ growth • spleen development • embryonic skeletal system morphogenesis • transmembrane transport • head morphogenesis • heme export Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	28982	226844
Ensembl	ENSG00000162769	ENSMUSG00000066595
UniProt	Q9Y5Y0	B2RXV4
RefSeq (mRNA)	NM_014053	NM_001081259
RefSeq (protein)	NP_054772	NP_001074728
Location (UCSC)	Chr 1: 212.86 – 212.9 Mb	Chr 1: 191.01 – 191.03 Mb
PubMed search

Feline leukemia virus subgroup C receptor-related protein 1 is a protein that in humans is encoded by the FLVCR1 gene.^[1][2][3]

References

1. Tailor CS, Willett BJ, Kabat D (1999). "A putative cell surface receptor for anemia-inducing feline leukemia virus subgroup C is a member of a transporter superfamily". J. Virol. 73 (8): 6500–5. PMC 112732. PMID 10400745.
2. Quigley JG, Burns CC, Anderson MM, Lynch ED, Sabo KM, Overbaugh J, Abkowitz JL (2000). "Cloning of the cellular receptor for feline leukemia virus subgroup C (FeLV-C), a retrovirus that induces red cell aplasia". Blood 95 (3): 1093–9. PMID 10648427.
3. "Entrez Gene: FLVCR feline leukemia virus subgroup C cellular receptor".

Further reading

• Lipovich L, Hughes AL, King MC, Abkowitz JL, Quigley JG (2002). "Genomic structure and evolutionary context of the human feline leukemia virus subgroup C receptor (hFLVCR) gene: evidence for block duplications and de novo gene formation within duplicons of the hFLVCR locus". Gene 286 (2): 203–13. doi:10.1016/S0378-1119(02)00457-2. PMID 11943475.
• Quigley JG, Yang Z, Worthington MT, Phillips JD, Sabo KM, Sabath DE, Berg CL, Sassa S, Wood BL, Abkowitz JL (2004). "Identification of a human heme exporter that is essential for erythropoiesis". Cell 118 (6): 757–66. doi:10.1016/j.cell.2004.08.014. PMID 15369674.
• Quigley JG, Gazda H, Yang Z, Ball S, Sieff CA, Abkowitz JL (2006). "Investigation of a putative role for FLVCR, a cytoplasmic heme exporter, in Diamond-Blackfan anemia". Blood Cells Mol. Dis. 35 (2): 189–92. doi:10.1016/j.bcmd.2005.01.005. PMID 15996880.
• Brown JK, Fung C, Tailor CS (2006). "Comprehensive mapping of receptor-functioning domains in feline leukemia virus subgroup C receptor FLVCR1". J. Virol. 80 (4): 1742–51. doi:10.1128/JVI.80.4.1742-1751.2006. PMC 1367145. PMID 16439531.