FMN reductase (NADPH)

FMN reductase (NADPH)
Identifiers
EC number	1.5.1.38
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

FMN reductase (NADPH) (EC 1.5.1.38, FRP, flavin reductase P, SsuE) is an enzyme with systematic name FMNH₂:NADP⁺ oxidoreductase.^{[1][2][3][4][5][6][7][8]} This enzyme catalyses the following chemical reaction:

FMNH2 + NADP⁺ $\rightleftharpoons$ FMN + NADPH + H⁺

The enzymes from bioluminescent bacteria contain FMN.

References

1. Gerlo, E. and Charlier, J. (1975). "Identification of NADH-specific and NADPH-specific FMN reductases in Beneckea harveyi". Eur. J. Biochem. 57 (2): 461–467. doi:10.1111/j.1432-1033.1975.tb02321.x. PMID 1175652.
2. Jablonski, E. and DeLuca, M. (1977). "Purification and properties of the NADH and NADPH specific FMN oxidoreductases from Beneckea harveyi". Biochemistry 16 (13): 2932–2936. doi:10.1021/bi00632a020. PMID 880288.
3. Jablonski, E. and DeLuca, M. (1978). "Studies of the control of luminescence in Beneckea harveyi: properties of the NADH and NADPH:FMN oxidoreductases". Biochemistry 17 (4): 672–678. doi:10.1021/bi00597a018. PMID 23827.
4. Lei, B., Liu, M., Huang, S. and Tu, S.C. (1994). "Vibrio harveyi NADPH-flavin oxidoreductase: cloning, sequencing and overexpression of the gene and purification and characterization of the cloned enzyme". J. Bacteriol. 176 (12): 3552–3558. PMC 205543. PMID 8206832.
5. Tanner, J.J., Lei, B., Tu, S.C. and Krause, K.L. (1996). "Flavin reductase P: structure of a dimeric enzyme that reduces flavin". Biochemistry 35 (42): 13531–13539. doi:10.1021/bi961400v. PMID 8885832.
6. Liu, M., Lei, B., Ding, Q., Lee, J.C. and Tu, S.C. (1997). "Vibrio harveyi NADPH:FMN oxidoreductase: preparation and characterization of the apoenzyme and monomer-dimer equilibrium". Arch. Biochem. Biophys. 337: 89–95. doi:10.1006/abbi.1996.9746. PMID 8990272.
7. Lei, B. and Tu, S.C. (1998). "Mechanism of reduced flavin transfer from Vibrio harveyi NADPH-FMN oxidoreductase to luciferase". Biochemistry 37: 14623–14629. doi:10.1021/bi981841. PMID 9772191.
8. Eichhorn, E., van der Ploeg, J.R. and Leisinger, T. (1999). "Characterization of a two-component alkanesulfonate monooxygenase from Escherichia coli". J. Biol. Chem. 274: 26639–26646. doi:10.1074/jbc.274.38.26639. PMID 10480865.

External links

• FMN reductase (NADPH) at the US National Library of Medicine Medical Subject Headings (MeSH)