FOLR2

Folate receptor 2 (fetal)
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4KMY​, 4KMZ​, 4KN0​, 4KN1​, 4KN2​
Identifiers
Symbols	FOLR2 ; BETA-HFR; FBP; FBP/PL-1; FR-BETA; FR-P3
External IDs	OMIM: 136425 MGI: 95569 HomoloGene: 627 ChEMBL: 5064 GeneCards: FOLR2 Gene
Gene ontology Molecular function • folic acid binding • drug binding • folic acid transporter activity • methotrexate binding • folic acid receptor activity Cellular component • extracellular region • cell surface • membrane • anchored component of external side of plasma membrane Biological process • monocyte chemotaxis • receptor-mediated endocytosis • inflammatory response • positive regulation of cell proliferation • folic acid transport • regulation of thymidylate synthase biosynthetic process • cellular response to folic acid Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2350	14276
Ensembl	ENSG00000165457	ENSMUSG00000032725
UniProt	P14207	Q05685
RefSeq (mRNA)	NM_000803	NM_001303231
RefSeq (protein)	NP_000794	NP_001290160
Location (UCSC)	Chr 11: 72.22 – 72.22 Mb	Chr 7: 101.84 – 101.85 Mb
PubMed search

Folate receptor beta is a protein that in humans is encoded by the FOLR2 gene.^[1][2][3]

The protein encoded by this gene is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus.^[3]

References

1. Kawasaki K, Fearnhead RW (Sep 1975). "On the relationship between tetracycline and the incremental lines in dentine". J Anat 119 (Pt 1): 49–59. PMC 1231614. PMID 1133088.
2. van Heyningen V, Little PF (May 1995). "Report of the fourth international workshop on human chromosome 11 mapping 1994". Cytogenet Cell Genet 69 (3-4): 127–58. doi:10.1159/000133953. PMID 7698003.
3. "Entrez Gene: FOLR2 folate receptor 2 (fetal)".

Further reading

• Henderson GB (1990). "Folate-binding proteins.". Annu. Rev. Nutr. 10: 319–35. doi:10.1146/annurev.nu.10.070190.001535. PMID 2166548.
• Ragoussis J, Senger G, Trowsdale J, Campbell IG (1992). "Genomic organization of the human folate receptor genes on chromosome 11q13.". Genomics 14 (2): 423–30. doi:10.1016/S0888-7543(05)80236-8. PMID 1330883.
• Freisheim JH, Price EM, Ratnam M (1990). "Folate coenzyme and antifolate transport proteins in normal and neoplastic cells.". Adv. Enzyme Regul. 29: 13–26. doi:10.1016/0065-2571(89)90091-5. PMID 2561247.
• Ratnam M, Marquardt H, Duhring JL, Freisheim JH (1990). "Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA.". Biochemistry 28 (20): 8249–54. doi:10.1021/bi00446a042. PMID 2605182.
• Yan W, Ratnam M (1995). "Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal.". Biochemistry 34 (44): 14594–600. doi:10.1021/bi00044a039. PMID 7578066.
• Sadasivan E, Cedeno MM, Rothenberg SP (1994). "Characterization of the gene encoding a folate-binding protein expressed in human placenta. Identification of promoter activity in a G-rich SP1 site linked with the tandemly repeated GGAAG motif for the ets encoded GA-binding protein.". J. Biol. Chem. 269 (7): 4725–35. PMID 8106441.
• Shen F, Ross JF, Wang X, Ratnam M (1994). "Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity.". Biochemistry 33 (5): 1209–15. doi:10.1021/bi00171a021. PMID 8110752.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Page ST, Owen WC, Price K, Elwood PC (1993). "Expression of the human placental folate receptor transcript is regulated in human tissues. Organization and full nucleotide sequence of the gene.". J. Mol. Biol. 229 (4): 1175–83. doi:10.1006/jmbi.1993.1116. PMID 8445646.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Wang J, Shen F, Yan W; et al. (1998). "Proteolysis of the carboxyl-terminal GPI signal independent of GPI modification as a mechanism for selective protein secretion.". Biochemistry 36 (47): 14583–92. doi:10.1021/bi970845w. PMID 9398177.
• Nakashima-Matsushita N, Homma T, Yu S; et al. (1999). "Selective expression of folate receptor beta and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis.". Arthritis Rheum. 42 (8): 1609–16. doi:10.1002/1529-0131(199908)42:8<1609::AID-ANR7>3.0.CO;2-L. PMID 10446858.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hao H, Qi H, Ratnam M (2003). "Modulation of the folate receptor type beta gene by coordinate actions of retinoic acid receptors at activator Sp1/ets and repressor AP-1 sites.". Blood 101 (11): 4551–60. doi:10.1182/blood-2002-10-3174. PMID 12543860.