FRS3
| Fibroblast growth factor receptor substrate 3 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | FRS3 ; FRS2-beta; FRS2B; FRS2beta; SNT-2; SNT2 | ||||||||||||
| External IDs | OMIM: 607744 MGI: 2135965 HomoloGene: 4845 GeneCards: FRS3 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10817 | 107971 | |||||||||||
| Ensembl | ENSG00000137218 | ENSMUSG00000023266 | |||||||||||
| UniProt | O43559 | Q91WJ0 | |||||||||||
| RefSeq (mRNA) | NM_006653 | NM_144939 | |||||||||||
| RefSeq (protein) | NP_006644 | NP_659188 | |||||||||||
| Location (UCSC) |
Chr 6: 41.77 – 41.79 Mb |
Chr 17: 47.69 – 47.7 Mb | |||||||||||
| PubMed search | |||||||||||||
Fibroblast growth factor receptor substrate 3 is a protein that in humans is encoded by the FRS3 gene.[1][2][3]
The protein encoded by this gene is a substrate for the fibroblast growth factor receptor. It is found in peripheral plasma membrane and functions in linking FGF receptor stimulation to activators of Ras.[3]
References
- ↑ Wang JK, Xu H, Li HC, Goldfarb M (Oct 1996). "Broadly expressed SNT-like proteins link FGF receptor stimulation to activators of Ras". Oncogene 13 (4): 721–9. PMID 8761293.
- ↑ Xu H, Lee KW, Goldfarb M (Aug 1998). "Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins". J Biol Chem 273 (29): 17987–90. doi:10.1074/jbc.273.29.17987. PMID 9660748.
- 1 2 "Entrez Gene: FRS3 fibroblast growth factor receptor substrate 3".
Further reading
- Lim YP, Low BC, Lim J; et al. (1999). "Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling.". J. Biol. Chem. 274 (27): 19025–34. doi:10.1074/jbc.274.27.19025. PMID 10383403.
- Ong SH, Guy GR, Hadari YR; et al. (2000). "FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors.". Mol. Cell. Biol. 20 (3): 979–89. doi:10.1128/MCB.20.3.979-989.2000. PMC 85215. PMID 10629055.
- Yamada M, Suzuki K, Mizutani M; et al. (2001). "Analysis of tyrosine phosphorylation-dependent protein-protein interactions in TrkB-mediated intracellular signaling using modified yeast two-hybrid system.". J. Biochem. 130 (1): 157–65. doi:10.1093/oxfordjournals.jbchem.a002955. PMID 11432792.
- Yan KS, Kuti M, Yan S; et al. (2002). "FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors.". J. Biol. Chem. 277 (19): 17088–94. doi:10.1074/jbc.M107963200. PMID 11877385.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ranzi V, Meakin SO, Miranda C; et al. (2003). "The signaling adapters fibroblast growth factor receptor substrate 2 and 3 are activated by the thyroid TRK oncoproteins.". Endocrinology 144 (3): 922–8. doi:10.1210/en.2002-221002. PMID 12586769.
- Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Gotoh N, Laks S, Nakashima M; et al. (2004). "FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts.". FEBS Lett. 564 (1-2): 14–8. doi:10.1016/S0014-5793(04)00287-X. PMID 15094036.
- Hassel S, Eichner A, Yakymovych M; et al. (2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry.". Proteomics 4 (5): 1346–58. doi:10.1002/pmic.200300770. PMID 15188402.
- Huang L, Gotoh N, Zhang S; et al. (2004). "SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation.". Biochem. Biophys. Res. Commun. 324 (3): 1011–7. doi:10.1016/j.bbrc.2004.09.152. PMID 15485655.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Harada A, Katoh H, Negishi M (2005). "Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells.". J. Biol. Chem. 280 (18): 18418–24. doi:10.1074/jbc.M411356200. PMID 15738000.
- Huang L, Watanabe M, Chikamori M; et al. (2006). "Unique role of SNT-2/FRS2beta/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways.". Oncogene 25 (49): 6457–66. doi:10.1038/sj.onc.1209656. PMID 16702953.
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