FSCN1

Fascin actin-bundling protein 1
PDB rendering based on 1dfc.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1DFC​, 3LLP​, 3O8K​, 3P53​, 4GOV​, 4GOY​, 4GP0​, 4GP3​
Identifiers
Symbols	FSCN1 ; FAN1; HSN; SNL; p55
External IDs	OMIM: 602689 MGI: 1352745 HomoloGene: 48164 GeneCards: FSCN1 Gene
Gene ontology Molecular function • actin binding • protein binding • drug binding • protein binding, bridging • poly(A) RNA binding • actin filament binding Cellular component • stress fiber • ruffle • podosome • cytoplasm • cytosol • cytoskeleton • microvillus • cell-cell junction • actin cytoskeleton • lamellipodium • filopodium • growth cone • cell projection membrane • myelin sheath • microspike • extracellular exosome • invadopodium Biological process • cell-cell junction assembly • cell proliferation • positive regulation of lamellipodium assembly • cell migration • microspike assembly • actin cytoskeleton organization • regulation of microvillus assembly • regulation of actin cytoskeleton organization • establishment of apical/basal cell polarity • cell motility • actin filament bundle assembly • positive regulation of filopodium assembly • positive regulation of podosome assembly • positive regulation of extracellular matrix disassembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6624	14086
Ensembl	ENSG00000075618	ENSMUSG00000029581
UniProt	Q16658	Q61553
RefSeq (mRNA)	NM_003088	NM_007984
RefSeq (protein)	NP_003079	NP_032010
Location (UCSC)	Chr 7: 5.59 – 5.61 Mb	Chr 5: 142.96 – 142.97 Mb
PubMed search

Fascin is a protein that in humans is encoded by the FSCN1 gene.^[1][2][3]

Interactions

FSCN1 has been shown to interact with Low affinity nerve growth factor receptor^[4] and PKC alpha.^[5]

References

1. Duh FM, Latif F, Weng Y, Geil L, Modi W, Stackhouse T, Matsumura F, Duan DR, Linehan WM, Lerman MI (Sep 1994). "cDNA cloning and expression of the human homolog of the sea urchin fascin and Drosophila singed genes which encodes an actin-bundling protein". DNA Cell Biol 13 (8): 821–7. doi:10.1089/dna.1994.13.821. PMID 8068206.
2. Tubb BE, Bardien-Kruger S, Kashork CD, Shaffer LG, Ramagli LS, Xu J, Siciliano MJ, Bryan J (Jul 2000). "Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes". Genomics 65 (2): 146–56. doi:10.1006/geno.2000.6156. PMID 10783262.
3. "Entrez Gene: FSCN1 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)".
4. Shonukan O, Bagayogo I, McCrea P, Chao M, Hempstead B (Jun 2003). "Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin". Oncogene 22 (23): 3616–23. doi:10.1038/sj.onc.1206561. PMID 12789270.
5. Anilkumar N, Parsons M, Monk R, Ng T, Adams JC (Oct 2003). "Interaction of fascin and protein kinase Cα: a novel intersection in cell adhesion and motility". EMBO J. 22 (20): 5390–402. doi:10.1093/emboj/cdg521. PMC 213775. PMID 14532112.

Further reading

• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
• Yamashiro-Matsumura S, Matsumura F (1985). "Purification and characterization of an F-actin-bundling 55-kilodalton protein from HeLa cells". J. Biol. Chem. 260 (8): 5087–97. PMID 3886649.
• Mosialos G, Yamashiro S, Baughman RW, Matsudaira P, Vara L, Matsumura F, Kieff E, Birkenbach M (1994). "Epstein-Barr virus infection induces expression in B lymphocytes of a novel gene encoding an evolutionarily conserved 55-kilodalton actin-bundling protein". J. Virol. 68 (11): 7320–8. PMC 237173. PMID 7933116.
• Mosialos G, Birkenbach M, Ayehunie S, Matsumura F, Pinkus GS, Kieff E, Langhoff E (1996). "Circulating human dendritic cells differentially express high levels of a 55-kd actin-bundling protein". Am. J. Pathol. 148 (2): 593–600. PMC 1861678. PMID 8579121.
• Yamakita Y, Ono S, Matsumura F, Yamashiro S (1996). "Phosphorylation of human fascin inhibits its actin binding and bundling activities". J. Biol. Chem. 271 (21): 12632–8. doi:10.1074/jbc.271.21.12632. PMID 8647875.
• Lin XH, Grako KA, Burg MA, Stallcup WB (1997). "NG2 proteoglycan and the actin-binding protein fascin define separate populations of actin-containing filopodia and lamellipodia during cell spreading and migration". Mol. Biol. Cell 7 (12): 1977–93. doi:10.1091/mbc.7.12.1977. PMC 276044. PMID 8970159.
• Ono S, Yamakita Y, Yamashiro S, Matsudaira PT, Gnarra JR, Obinata T, Matsumura F (1997). "Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin". J. Biol. Chem. 272 (4): 2527–33. doi:10.1074/jbc.272.4.2527. PMID 8999969.
• Pinkus GS, Pinkus JL, Langhoff E, Matsumura F, Yamashiro S, Mosialos G, Said JW (1997). "Fascin, a sensitive new marker for Reed-Sternberg cells of hodgkin's disease. Evidence for a dendritic or B cell derivation?". Am. J. Pathol. 150 (2): 543–62. PMC 1858289. PMID 9033270.
• Ross R, Ross XL, Schwing J, Längin T, Reske-Kunz AB (1998). "The actin-bundling protein fascin is involved in the formation of dendritic processes in maturing epidermal Langerhans cells". J. Immunol. 160 (8): 3776–82. PMID 9558080.
• Sonderbye L, Meehan S, Palsson R, Ahsan N, Ladefoged J, Langhoff E (1998). "Immunohistochemical study of actin binding protein (p55) in the human kidney". Transplantation 65 (7): 1004–8. doi:10.1097/00007890-199804150-00025. PMID 9565110.
• Kempf W, Levi E, Kamarashev J, Kutzner H, Pfeifer W, Petrogiannis-Haliotis T, Burg G, Kadin ME (2003). "Fascin expression in CD30-positive cutaneous lymphoproliferative disorders". J. Cutan. Pathol. 29 (5): 295–300. doi:10.1034/j.1600-0560.2002.290507.x. PMID 12100631.
• Goncharuk VN, Ross JS, Carlson JA (2003). "Actin-binding protein fascin expression in skin neoplasia". J. Cutan. Pathol. 29 (7): 430–8. doi:10.1034/j.1600-0560.2002.290708.x. PMID 12139639.
• Pelosi G, Pastorino U, Pasini F, Maissoneuve P, Fraggetta F, Iannucci A, Sonzogni A, De Manzoni G, Terzi A, Durante E, Bresaola E, Pezzella F, Viale G (2003). "Independent prognostic value of fascin immunoreactivity in stage I nonsmall cell lung cancer". Br. J. Cancer 88 (4): 537–47. doi:10.1038/sj.bjc.6600731. PMC 2377175. PMID 12592367.
• Shonukan O, Bagayogo I, McCrea P, Chao M, Hempstead B (2003). "Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin". Oncogene 22 (23): 3616–23. doi:10.1038/sj.onc.1206561. PMID 12789270.
• Bros M, Ross XL, Pautz A, Reske-Kunz AB, Ross R (2003). "The human fascin gene promoter is highly active in mature dendritic cells due to a stage-specific enhancer". J. Immunol. 171 (4): 1825–34. doi:10.4049/jimmunol.171.4.1825. PMID 12902483.
• Anilkumar N, Parsons M, Monk R, Ng T, Adams JC (2004). "Interaction of fascin and protein kinase Cα: a novel intersection in cell adhesion and motility". EMBO J. 22 (20): 5390–402. doi:10.1093/emboj/cdg521. PMC 213775. PMID 14532112.
• Ishikawa R, Sakamoto T, Ando T, Higashi-Fujime S, Kohama K (2003). "Polarized actin bundles formed by human fascin-1: their sliding and disassembly on myosin II and myosin V in vitro". J. Neurochem. 87 (3): 676–85. doi:10.1046/j.1471-4159.2003.02058.x. PMID 14535950.