FSTL3

Follistatin-like 3 (secreted glycoprotein)
Rendering based on PDB 2KCX​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2KCX​, 3B4V​, 3SEK​
Identifiers
Symbols	FSTL3 ; FLRG; FSRP
External IDs	OMIM: 605343 MGI: 1890391 HomoloGene: 4280 GeneCards: FSTL3 Gene
Gene ontology Molecular function • fibronectin binding • protein binding • activin binding Cellular component • extracellular region • extracellular space • nucleus • nucleoplasm • Golgi apparatus • secretory granule • neuron projection terminus Biological process • ossification • kidney development • hematopoietic progenitor cell differentiation • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • spermatogenesis • male gonad development • positive regulation of cell-cell adhesion • lung development • adrenal gland development • negative regulation of BMP signaling pathway • negative regulation of activin receptor signaling pathway • negative regulation of osteoclast differentiation • positive regulation of transcription from RNA polymerase II promoter • cellular response to metal ion • negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10272	83554
Ensembl	ENSG00000070404	ENSMUSG00000020325
UniProt	O95633	Q9EQC7
RefSeq (mRNA)	NM_005860	NM_031380
RefSeq (protein)	NP_005851	NP_113557
Location (UCSC)	Chr 19: 0.68 – 0.68 Mb	Chr 10: 79.78 – 79.78 Mb
PubMed search

Follistatin-related protein 3 is a protein that in humans is encoded by the FSTL3 gene.^[1][2][3]

Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis.^[3]

References

1. Hayette S, Gadoux M, Martel S, Bertrand S, Tigaud I, Magaud JP, Rimokh R (Aug 1998). "FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders". Oncogene 16 (22): 2949–54. doi:10.1038/sj.onc.1201807. PMID 9671416.
2. Glusman G, Kaur A, Hood L, Rowen L (Nov 2004). "An enigmatic fourth runt domain gene in the fugu genome: ancestral gene loss versus accelerated evolution". BMC Evol Biol 4: 43. doi:10.1186/1471-2148-4-43. PMC 533870. PMID 15527507.
3. "Entrez Gene: FSTL3 follistatin-like 3 (secreted glycoprotein)".

Further reading

• Maguer-Satta V, Rimokh R (2005). "FLRG, member of the follistatin family, a new player in hematopoiesis.". Mol. Cell. Endocrinol. 225 (1–2): 109–18. doi:10.1016/j.mce.2004.07.009. PMID 15451575.
• Dias Neto E, Correa RG, Verjovski-Almeida S; et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Tortoriello DV, Sidis Y, Holtzman DA; et al. (2001). "Human follistatin-related protein: a structural homologue of follistatin with nuclear localization". Endocrinology 142 (8): 3426–34. doi:10.1210/en.142.8.3426. PMID 11459787.
• Bartholin L, Maguer-Satta V, Hayette S; et al. (2001). "FLRG, an activin-binding protein, is a new target of TGFbeta transcription activation through Smad proteins". Oncogene 20 (39): 5409–19. doi:10.1038/sj.onc.1204720. PMID 11571638.
• Bartholin L, Maguer-Satta V, Hayette S; et al. (2002). "Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function". Oncogene 21 (14): 2227–35. doi:10.1038/sj.onc.1205294. PMID 11948405.
• Hill JJ, Davies MV, Pearson AA; et al. (2002). "The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum". J. Biol. Chem. 277 (43): 40735–41. doi:10.1074/jbc.M206379200. PMID 12194980.
• Liu J, Vänttinen T, Hydén-Granskog C, Voutilainen R (2003). "Regulation of follistatin-related gene (FLRG) expression by protein kinase C and prostaglandin E(2) in cultured granulosa-luteal cells". Mol. Hum. Reprod. 8 (11): 992–7. doi:10.1093/molehr/8.11.992. PMID 12397211.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Maguer-Satta V, Bartholin L, Jeanpierre S; et al. (2003). "Regulation of human erythropoiesis by activin A, BMP2, and BMP4, members of the TGFbeta family". Exp. Cell Res. 282 (2): 110–20. doi:10.1016/S0014-4827(02)00013-7. PMID 12531697.
• Wang HQ, Takebayashi K, Tsuchida K; et al. (2003). "Follistatin-related gene (FLRG) expression in human endometrium: sex steroid hormones regulate the expression of FLRG in cultured human endometrial stromal cells". J. Clin. Endocrinol. Metab. 88 (9): 4432–9. doi:10.1210/jc.2002-021758. PMID 12970321.
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Xia Y, Sidis Y, Schneyer A (2004). "Overexpression of follistatin-like 3 in gonads causes defects in gonadal development and function in transgenic mice". Mol. Endocrinol. 18 (4): 979–94. doi:10.1210/me.2003-0364. PMID 14739256.
• Florio P, Ciarmela P, Toti P; et al. (2004). "Human endometrium and decidua express follistatin-related gene (FLRG) mRNA and peptide". Mol. Cell. Endocrinol. 218 (1–2): 129–35. doi:10.1016/j.mce.2003.12.019. PMID 15130517.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Saito S, Sidis Y, Mukherjee A; et al. (2006). "Differential biosynthesis and intracellular transport of follistatin isoforms and follistatin-like-3". Endocrinology 146 (12): 5052–62. doi:10.1210/en.2005-0833. PMID 16150905.
• Okamoto A, Endo H, Kalionis B; et al. (2006). "IGFBP1 and Follistatin-like 3 genes are significantly up-regulated in expression profiles of the IUGR placenta". Placenta 27 (2–3): 317–21. doi:10.1016/j.placenta.2004.12.007. PMID 16338475.

External links

• FSTL3 human gene location in the UCSC Genome Browser.
• FSTL3 human gene details in the UCSC Genome Browser.