Fasciclin domain

Fasciclin

solution structure of the antigenic tb protein mpt70/mpb70
Identifiers
Symbol Fasciclin
Pfam PF02469
InterPro IPR000782
SCOP 1o70
SUPERFAMILY 1o70

In molecular biology, the fasciclin domain (FAS1 domain) is an extracellular domain of about 140 amino acid residues. It has been suggested that the FAS1 domain represents an ancient cell adhesion domain common to plants and animals;[1] related FAS1 domains are also found in bacteria.[2]

The crystal structure of FAS1 domains 3 and 4 of fasciclin I from Drosophila melanogaster (Fruit fly) has been determined, revealing a novel domain fold consisting of a seven-stranded beta wedge and at least five alpha helices; two well-ordered N-acetylglucosamine groups attached to a conserved asparagine are located in the interface region between the two FAS1 domains.[3] Fasciclin I is an insect neural cell adhesion molecule involved in axonal guidance that is attached to the membrane by a GPI-anchored protein.

FAS1 domains are present in many secreted and membrane-anchored proteins. These proteins are usually GPI anchored and consist of: (i) a single FAS1 domain, (ii) a tandem array of FAS1 domains, or (iii) FAS1 domain(s) interspersed with other domains.

Proteins known to contain a FAS1 domain include:

The FAS1 domains of both human periostin and BIgH3 proteins were found to contain vitamin K-dependent gamma-carboxyglutamate residues.[8] Gamma-carboxyglutamate residues are more commonly associated with GLA domains, where they occur through post-translational modification catalysed by the vitamin K-dependent enzyme gamma-glutamylcarboxylase.

See also

References

  1. 1 2 Huber O, Sumper M (September 1994). "Algal-CAMs: isoforms of a cell adhesion molecule in embryos of the alga Volvox with homology to Drosophila fasciclin I". EMBO J. 13 (18): 4212–22. PMC 395348. PMID 7925267. C1 control character in |pages= at position 6 (help)
  2. ↑ Ulstrup JC, Jeansson S, Wiker HG, Harboe M (February 1995). "Relationship of secretion pattern and MPB70 homology with osteoblast-specific factor 2 to osteitis following Mycobacterium bovis BCG vaccination". Infect. Immun. 63 (2): 672–5. PMC 173047. PMID 7822037. C1 control character in |pages= at position 5 (help)
  3. ↑ Clout NJ, Tisi D, Hohenester E (February 2003). "Novel fold revealed by the structure of a FAS1 domain pair from the insect cell adhesion molecule fasciclin I". Structure 11 (2): 197–203. doi:10.1016/S0969-2126(03)00002-9. PMID 12575939. C1 control character in |pages= at position 5 (help)
  4. ↑ Kim JE, Kim SJ, Lee BH, Park RW, Kim KS, Kim IS (October 2000). "Identification of motifs for cell adhesion within the repeated domains of transforming growth factor-beta-induced gene, betaig-h3". J. Biol. Chem. 275 (40): 30907–15. doi:10.1074/jbc.M002752200. PMID 10906123. C1 control character in |pages= at position 7 (help)
  5. ↑ Faik A, Abouzouhair J, Sarhan F (November 2006). "Putative fasciclin-like arabinogalactan-proteins (FLA) in wheat (Triticum aestivum) and rice (Oryza sativa): identification and bioinformatic analyses". Mol. Genet. Genomics 276 (5): 478–94. doi:10.1007/s00438-006-0159-z. PMID 16944204. C1 control character in |pages= at position 5 (help)
  6. ↑ Kzhyshkowska J, Gratchev A, Martens JH, Pervushina O, Mamidi S, Johansson S, Schledzewski K, Hansen B, He X, Tang J, Nakayama K, Goerdt S (December 2004). "Stabilin-1 localizes to endosomes and the trans-Golgi network in human macrophages and interacts with GGA adaptors". J. Leukoc. Biol. 76 (6): 1151–61. doi:10.1189/jlb.0504300. PMID 15345724. C1 control character in |pages= at position 6 (help)
  7. ↑ Matsumoto S, Matsuo T, Ohara N, Hotokezaka H, Naito M, Minami J, Yamada T (March 1995). "Cloning and sequencing of a unique antigen MPT70 from Mycobacterium tuberculosis H37Rv and expression in BCG using E. coli-mycobacteria shuttle vector". Scand. J. Immunol. 41 (3): 281–7. doi:10.1111/j.1365-3083.1995.tb03565.x. PMID 7871388. C1 control character in |pages= at position 5 (help)
  8. ↑ Coutu DL, Wu JH, Monette A, Rivard GE, Blostein MD, Galipeau J (June 2008). "Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells". J. Biol. Chem. 283 (26): 17991–8001. doi:10.1074/jbc.M708029200. PMID 18450759. C1 control character in |pages= at position 7 (help)

This article incorporates text from the public domain Pfam and InterPro IPR000782

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