Fenleuton

Fenleuton
Systematic (IUPAC) name

1-{4-[3-(4-Fluorophenoxy)phenyl]-3-butyn-2-yl}-1-hydroxyurea
Identifiers
ChemSpider	65045
Chemical data
Formula	C₁₇H₁₄FN₂O₃
Molar mass	314.107 g/mol
SMILES CC(C#Cc1cccc(c1)Oc2ccc(cc2)F)N(C(=O)N)O
InChI InChI=InChI=1S/C17H15FN2O3/c1-12(20(22)17(19)21)5-6-13-3-2-4-16(11-13)23-15-9-7-14(18)8-10-15/h2-4,7-12,22H,1H3,(H2,19,21) Key:MWXPQCKCKPYBDR-UHFFFAOYSA-N^[1]

Fenleuton acts as 5-lipoxygenase inhibitor that inhibits leukotriene (LTB4, LTC4, LTD4, and LTE4) formation. It has been studied for potential use in veterinary medicine to treat respiratory diseases such as chronic obstructive pulmonary disease (COPD) in horses.^[2]

References

↑ "1-{4-[3-(4-Fluorophenoxy)phenyl]-3-butyn-2-yl}-1-hydroxyurea". chemspider.com. Retrieved 24 December 2015.
↑ Marr KA, Lees P, Page CP, Cunningham FM (1998). "Effect of the 5-lipoxygenase inhibitor, fenleuton, on antigen-induced neutrophil accumulation and lung function changes in horses with chronic obstructive pulmonary disease". J Vet Pharmacol Ther 21 (3): 241–246. PMID 9673966.

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