Fetuin-B
| Fetuin B | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | FETUB ; 16G2; Gugu; IRL685 | ||||||||||||
| External IDs | OMIM: 605954 MGI: 1890221 HomoloGene: 8660 GeneCards: FETUB Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 26998 | 59083 | |||||||||||
| Ensembl | ENSG00000090512 | ENSMUSG00000022871 | |||||||||||
| UniProt | Q9UGM5 | Q9QXC1 | |||||||||||
| RefSeq (mRNA) | NM_001308077 | NM_001083904 | |||||||||||
| RefSeq (protein) | NP_001295006 | NP_001077373 | |||||||||||
| Location (UCSC) |
Chr 3: 186.64 – 186.65 Mb |
Chr 16: 22.92 – 22.94 Mb | |||||||||||
| PubMed search | |||||||||||||
Fetuin-B is a protein that in humans is encoded by the FETUB gene.[1][2]
The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells.[2]
See also
- Fetuin-A (alpha-2-HS-glycoprotein)
References
- ↑ Olivier E, Soury E, Ruminy P, Husson A, Parmentier F, Daveau M, Salier JP (Jan 2001). "Fetuin-B, a second member of the fetuin family in mammals". Biochem J. 350 Pt 2: 589–97. doi:10.1042/0264-6021:3500589. PMC 1221288. PMID 10947975.
- 1 2 "Entrez Gene: FETUB fetuin B".
Further reading
- Haidar M, Seddiki N, Gluckman JC, Gattegno L (1993). "Carbohydrate binding properties of the envelope glycoproteins of human immunodeficiency virus type 1.". Glycoconj. J. 9 (6): 315–23. doi:10.1007/BF00731092. PMID 1284814.
- Hillier LD, Lennon G, Becker M; et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Denecke B, Gräber S, Schäfer C; et al. (2003). "Tissue distribution and activity testing suggest a similar but not identical function of fetuin-B and fetuin-A.". Biochem. J. 376 (Pt 1): 135–45. doi:10.1042/BJ20030676. PMC 1223762. PMID 12943536.
- Wajih N, Borras T, Xue W; et al. (2004). "Processing and transport of matrix gamma-carboxyglutamic acid protein and bone morphogenetic protein-2 in cultured human vascular smooth muscle cells: evidence for an uptake mechanism for serum fetuin.". J. Biol. Chem. 279 (41): 43052–60. doi:10.1074/jbc.M407180200. PMID 15280384.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Hsu SJ, Nagase H, Balmain A (2005). "Identification of Fetuin-B as a member of a cystatin-like gene family on mouse chromosome 16 with tumor suppressor activity.". Genome 47 (5): 931–46. doi:10.1139/g04-043. PMID 15499407.
- Liu T, Qian WJ, Gritsenko MA; et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
- Coen G, Ballanti P, Balducci A; et al. (2006). "Renal osteodystrophy: alpha-Heremans Schmid glycoprotein/fetuin-A, matrix GLA protein serum levels, and bone histomorphometry.". Am. J. Kidney Dis. 48 (1): 106–13. doi:10.1053/j.ajkd.2006.03.083. PMID 16797392.
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