Fibrin glue

Fibrin glue applied after drying the scleral bed in an intraocular lens operation

Fibrin glue (also called Fibrin sealant) is a formulation used to create a fibrin clot.[1][2][3][4][5][6][7]

Composition

It is made up of fibrinogen (lyophilised pooled human concentrate) and thrombin (bovine, which is reconstituted with calcium chloride)[1] that are applied to the tissue sites to glue them together.[1] Thrombin is an enzyme and converts fibrinogen into fibrin monomers between 10 and 60 seconds giving rise to a three-dimensional gel.[6][8]

Factors affecting structure

Factors that influence dimensional structure of fibrin gel giving rise to fine or coarse gel

  1. Changing concentration of fibrinogen
  2. Changing concentration of thrombine- increase concentration increases ultimate tensile strength and youngs modulus of gel
  3. Changing concentration of calcium
  4. pH
  5. Temperature

It may also contain aprotinin, fibronectin and plasminogen.[9] This glue can be used for repairing dura tears, bronchial fistulas and for achieving hemostasis after spleen and liver trauma.[6] It is also employed in "no sutures" corneal transplantation, pterygium excision with amniotic membrane or conjunctival autograft, and in ocular trauma for corneal or conjunctival defects.[10][11] [12]


References

  1. 1 2 3 http://www.bmj.com/cgi/content/extract/308/6934/933
  2. ↑ http://www.theannals.com/cgi/content/abstract/22/12/946
  3. ↑ http://www.medhelp.org/forums/gastro/archive/1054.html
  4. ↑ http://content.karger.com/ProdukteDB/produkte.asp?Doi=8552
  5. ↑ http://www.healthsystem.virginia.edu/internet/stac/research/spfibgl.cfm
  6. 1 2 3 http://www.ijps.org/article.asp?issn=0970-0358;year=2003;volume=36;issue=1;spage=14;epage=17;aulast=Saxena
  7. ↑ http://www3.interscience.wiley.com/journal/121466570/abstract
  8. ↑ Spotnitz, W. . (2009). "Fibrin Sealant: Past, Present, and Future: A Brief Review". World journal of surgery 34 (4): 632–634. doi:10.1007/s00268-009-0252-7. PMID 19820991.
  9. ↑ Tisseel From the Swedish official drug catalog
  10. ↑ Narendran N, Mohamed S, Shah S (July 2007). "No sutures corneal grafting--a novel use of overlay sutures and fibrin glue in Deep Anterior Lamellar Keratoplasty". Cont Lens Anterior Eye 30 (3): 207–9. doi:10.1016/j.clae.2007.02.007. PMID 17379570.
  11. ↑ Dal Pizzol, MM; Roggia, MF; Kwitko, S; Marinho, DR; Rymer, S (2009). "Use of fibrin glue in ocular surgery". Arquivos brasileiros de oftalmologia 72 (3): 308–12. PMID 19668958.
  12. ↑ Vivostat - Autologus Fibrin Sealant - PubMed link


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